Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077160 | 0.79 | AKR1B1 (0.46) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL28498656 | 0.76 | GRIN1 (0.45) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL13541879 | 0.75 | AKR1B1 (0.40) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL3666780 | 0.72 | MEN1 (0.47) | OPRK1OPRM1MEN1ALDH1A1KMT2A | |
| SCHEMBL11674801 | 0.69 | MEN1 (0.53) | LMNAKDM4EPKMMEN1ALDH1A1 | |
| SCHEMBL10042118 | 0.68 | AKR1B1 (0.38) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL13853045 | 0.68 | OPRM1 (0.41) | OPRK1LMNAOPRM1AKR1B1MEN1 | |
| SCHEMBL1944655 | 0.67 | MEN1 (0.45) | GRIN1GRIN2ASLC6A4GRIN2DGRIN3B | |
| SCHEMBL18440769 | 0.67 | PDE7A (0.38) | SLC6A4PDE7A | |
| SCHEMBL13543578 | 0.67 | GAA (0.30) | MAPTKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642283-B2 | modulating the activity of the mitochrondrial permeability transition pore complex comprising exposing the complex to a compound such as 6-bromo-3-methylene-chroman-4-one | HOFFMANN-LA ROCHE INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-7642283-B2 | modulating the activity of the mitochrondrial permeability transition pore complex comprising exposing the complex to a compound such as 6-bromo-3-methylene-chroman-4-one | HOFFMANN-LA ROCHE INC. (US) | 2010-01-05 | — | — | US | disclosed |
| EP-1468995-B1 | MPTP affinity labels | HOFFMANN LA ROCHE (CH) | 2008-05-14 | — | — | EP | disclosed |
| US-20060252822-A1 | Mitochrondrial permeability transition pore affinity labels and modulators | CESURA ANDREA | 2006-11-09 | — | — | US | disclosed |
| US-7101917-B2 | Mitochrondrial permeability transition pore affinity labels and modulators | HOFFMANN-LA ROCHE INC. (US) | 2006-09-05 | — | — | US | disclosed |
| US-20040220257-A1 | Mitochrondrial permeability transition pore affinity labels and modulators | HOFFMANN-LA ROCHE INC. | 2004-11-04 | — | — | US | disclosed |
| EP-1468995-A1 | MPTP affinity labels | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220257-A1 | Mitochrondrial permeability transition pore affinity labels and modulators | MCU, ATP5PB, MFN2 | GRIN1 1182/4885GRIN2A 1521/4885SLC6A4 842/4885 |
| US-20060252822-A1 | Mitochrondrial permeability transition pore affinity labels and modulators | MCU, ATP5PB, MFN2 | GRIN1 1182/4885GRIN2A 1521/4885SLC6A4 842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.