Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR2 | Q969V1 | 10/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.41 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12084445 | 0.89 | MCHR2 (0.53) | MCHR2DRD2SLC6A4KCNH2CHRM4 | |
| SCHEMBL2758250 | 0.82 | MCHR2 (0.60) | MCHR2DRD2SLC6A4KCNH2HSD11B1 | |
| SCHEMBL12293251 | 0.80 | MCHR2 (0.60) | MCHR2DRD2SLC6A4KCNH2HSD11B1 | |
| SCHEMBL2758228 | 0.79 | MCHR2 (0.61) | MCHR2DRD2SLC6A4KCNH2HSD11B1 | |
| SCHEMBL2758239 | 0.79 | MCHR2 (0.59) | MCHR2DRD2SLC6A4KCNH2HSD11B1 | |
| SCHEMBL9089853 | 0.79 | HSD11B1 (0.46) | MCHR2DRD2SLC6A4KCNH2HSD11B1 | |
| SCHEMBL13207690 | 0.78 | MCHR2 (0.56) | MCHR2DRD2SLC6A4KCNH2HSD11B1 | |
| SCHEMBL2758231 | 0.78 | MCHR2 (0.58) | MCHR2DRD2SLC6A4KCNH2HSD11B1 | |
| SCHEMBL2758236 | 0.78 | MCHR2 (0.58) | MCHR2DRD2SLC6A4KCNH2HSD11B1 | |
| SCHEMBL13000095 | 0.78 | MCHR2 (0.55) | MCHR2DRD2SLC6A4KCNH2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858635-B2 | Spiro compounds as modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-28 | — | — | US | disclosed |
| EP-1973543-A2 | MODULATORS OF MUSCARINIC RECEPTORS | Vertex Pharmaceuticals Incorporated (US) | 2008-10-01 | — | — | EP | disclosed |
| US-20080015179-A1 | Modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED | 2008-01-17 | — | — | US | disclosed |
| WO-2007076070-A2 | MODULATORS OF MUSCARINIC RECEPTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015179-A1 | Modulators of muscarinic receptors | CHRM3, CHRM5, CHRM2 | MCHR2 159/4885DRD2 757/4885SLC6A4 1025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.