Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA4 | P22459 | 1/20 | 0.40 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.40 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13959269 | 0.77 | — | — | |
| SCHEMBL3265548 | 0.77 | KCNA4 (0.40) | KCNA4KCNA1KCNAB1 | |
| SCHEMBL1471940 | 0.77 | KCNA4 (0.40) | KCNA4KCNA1KCNAB1 | |
| SCHEMBL14649692 | 0.77 | KCNA4 (0.40) | KCNA4KCNA1KCNAB1 | |
| SCHEMBL18919238 | 0.72 | KCNA4 (0.37) | KCNA4KCNA1KCNAB1 | |
| SCHEMBL555211 | 0.72 | KCNA4 (0.37) | KCNA4KCNA1KCNAB1 | |
| SCHEMBL13897196 | 0.72 | KCNA4 (0.37) | KCNA4KCNA1KCNAB1 | |
| SCHEMBL21216529 | 0.72 | KCNA4 (0.37) | KCNA4KCNA1KCNAB1 | |
| SCHEMBL19425925 | 0.72 | KCNA4 (0.37) | KCNA4KCNA1KCNAB1 | |
| SCHEMBL13897204 | 0.72 | KCNA4 (0.37) | KCNA4KCNA1KCNAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1854792-B1 | 1-(2H)-ISOQUINOLONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2012-12-26 | — | — | EP | disclosed |
| US-7820693-B2 | 1-(2H)-isoquinolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-10-26 | — | — | US | disclosed |
| US-20090030195-A1 | 1-(2H)-ISOQUINOLONE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-01-29 | — | — | US | disclosed |
| EP-1854792-A1 | 1-(2H)-ISOQUINOLONE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-11-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030195-A1 | 1-(2H)-ISOQUINOLONE DERIVATIVE | NQO1, NR5A1, SRD5A1 | KCNA4 3031/4885KCNA1 905/4885KCNAB1 2314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.