Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 19/20 | 0.58 |
| ▸ | CTSS | P25774 | 10/20 | 0.56 |
| ▸ | CTSL | P07711 | 8/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3547672 | 0.92 | CTSK (0.66) | CTSKCTSSCTSL | |
| SCHEMBL3540655 | 0.92 | CTSK (0.60) | CTSKCTSSCTSLCTSB | |
| SCHEMBL3551753 | 0.92 | CTSK (0.60) | CTSKCTSSCTSLCTSB | |
| SCHEMBL3538541 | 0.91 | CTSK (0.60) | CTSKCTSSCTSLCTSB | |
| SCHEMBL3548120 | 0.91 | CTSK (0.60) | CTSKCTSSCTSLCTSB | |
| SCHEMBL3542572 | 0.91 | CTSK (0.60) | CTSKCTSSCTSLCTSB | |
| SCHEMBL3547493 | 0.91 | CTSK (0.60) | CTSKCTSSCTSLCTSB | |
| SCHEMBL3546129 | 0.91 | CTSK (0.60) | CTSKCTSSCTSLCTSB | |
| SCHEMBL3545627 | 0.91 | CTSK (0.59) | CTSKCTSSCTSLCTSB | |
| SCHEMBL3542112 | 0.90 | CTSK (0.72) | CTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799791-B2 | Tetrahydrofuro(3,2-B) pyrrol-3-one derivatives as inhibitors of cysteine proteinases | AMURA THERAPEUTICS LIMITED (GB) | 2010-09-21 | — | — | US | claimed |
| US-20090186831-A1 | Tetrahydrofuro(3,2-B) pyrrol-3-one derivatives as inhibitors of cysteine proteinases | AMURA THERAPEUTICS LIMITED (GB) | 2009-07-23 | — | — | US | claimed |
| US-7799791-B2 | Tetrahydrofuro(3,2-B) pyrrol-3-one derivatives as inhibitors of cysteine proteinases | AMURA THERAPEUTICS LIMITED (GB) | 2010-09-21 | — | — | US | disclosed |
| US-20090186831-A1 | Tetrahydrofuro(3,2-B) pyrrol-3-one derivatives as inhibitors of cysteine proteinases | AMURA THERAPEUTICS LIMITED (GB) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186831-A1 | Tetrahydrofuro(3,2-B) pyrrol-3-one derivatives as inhibitors of cysteine proteinases | TMPRSS6, CCR6, MMP8 | CTSK 496/4885CTSS 33/4885CTSL 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.