Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 18/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089261 | 0.89 | PIN1 (0.43) | PIN1MAPTALDH1A1 | |
| SCHEMBL3547171 | 0.79 | PIN1 (0.45) | PIN1MAPTALDH1A1 | |
| SCHEMBL3547175 | 0.78 | PIN1 (0.44) | PIN1MAPTALDH1A1 | |
| SCHEMBL1204074 | 0.77 | PIN1 (0.43) | PIN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL14941630 | 0.76 | PIN1 (0.44) | PIN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3541923 | 0.76 | PIN1 (0.35) | PIN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL14941629 | 0.76 | PIN1 (0.44) | PIN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4077793 | 0.74 | PIN1 (0.47) | PIN1ALDH1A1 | |
| SCHEMBL1288393 | 0.73 | PIN1 (0.43) | PIN1MAPTALDH1A1 | |
| SCHEMBL3621457 | 0.72 | PIN1 (0.41) | PIN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709471-B2 | Compounds | ASTRAZENECA AB (SE) | 2010-05-04 | — | — | US | disclosed |
| US-20080009482-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009482-A1 | NOVEL COMPOUNDS | CYP11B2, CYP11B1, CYP46A1 | PIN1 2833/4885MAPT 2200/4885ALDH1A1 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.