Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 4/20 | 0.63 |
| ▸ | DPP4 | P27487 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3545238 | 0.89 | CCR5 (0.54) | CCR5DPP4ALDH1A1KDM4EGLA | |
| SCHEMBL3553193 | 0.89 | CCR5 (0.54) | CCR5DPP4ALDH1A1KDM4EGLA | |
| SCHEMBL3553189 | 0.89 | CCR5 (0.54) | CCR5DPP4ALDH1A1KDM4EGLA | |
| SCHEMBL1937441 | 0.88 | DPP4 (0.70) | CCR5DPP4ALDH1A1KDM4EGLA | |
| SCHEMBL3557153 | 0.88 | CCR5 (0.57) | CCR5DPP4ALDH1A1SIGMAR1MEN1 | |
| SCHEMBL3551204 | 0.88 | CCR5 (0.57) | CCR5DPP4ALDH1A1SIGMAR1MEN1 | |
| SCHEMBL3559501 | 0.88 | CCR5 (0.57) | CCR5DPP4ALDH1A1SIGMAR1MEN1 | |
| SCHEMBL3557156 | 0.88 | CCR5 (0.57) | CCR5DPP4ALDH1A1SIGMAR1MEN1 | |
| SCHEMBL3559498 | 0.88 | CCR5 (0.57) | CCR5DPP4ALDH1A1SIGMAR1MEN1 | |
| SCHEMBL3546941 | 0.86 | CCR5 (0.64) | CCR5DPP4DRD2BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087485-A1 | 4-AMINOPIPERIDINE DERIVATIVES | BOEHRINGER MARKUS | 2010-04-08 | — | — | US | disclosed |
| US-7683079-B2 | 4-aminopiperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-23 | — | — | US | disclosed |
| CN-101090888-A | 4-aminopiperidine derivatives | HOFFMANN LA ROCHE (CH) | 2007-12-19 | — | — | CN | disclosed |
| US-20060135561-A1 | 4-Aminopiperidine derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087485-A1 | 4-AMINOPIPERIDINE DERIVATIVES | DPP4, GPR119, IAPP | CCR5 2106/4885DPP4 1/4885ALDH1A1 199/4885 |
| US-20060135561-A1 | 4-Aminopiperidine derivatives | DPP4, GPR119, IAPP | CCR5 2106/4885DPP4 1/4885ALDH1A1 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.