Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.63 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RHEB | Q15382 | 3/20 | 0.45 |
| ▸ | SPR | P35270 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | TPMT | P51580 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20875014 | 0.80 | NR4A2 (0.46) | AURKATPX2ALDH1A1RHEBFTO | |
| SCHEMBL2806054 | 0.80 | AURKA (0.56) | AURKATPX2ALDH1A1KDM4EHPGD | |
| SCHEMBL30446838 | 0.80 | AURKA (0.56) | AURKATPX2ALDH1A1KDM4EHPGD | |
| SCHEMBL7163885 | 0.80 | AURKA (0.56) | AURKATPX2ALDH1A1KDM4EHPGD | |
| SCHEMBL3541516 | 0.79 | AURKA (0.55) | AURKATPX2ALDH1A1KDM4EHPGD | |
| SCHEMBL3545296 | 0.79 | AURKA (0.55) | AURKATPX2ALDH1A1KDM4EHPGD | |
| SCHEMBL30829598 | 0.79 | AURKA (0.55) | AURKATPX2ALDH1A1KDM4EHPGD | |
| SCHEMBL22778110 | 0.77 | AURKA (0.41) | AURKATPX2ALDH1A1KDM4EHPGD | |
| SCHEMBL29714385 | 0.77 | AURKA (0.41) | AURKATPX2ALDH1A1KDM4EHPGD | |
| SCHEMBL2172545 | 0.75 | KDM4E (0.61) | AURKATPX2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109915-A1 | NOVEL ACC INHIBITORS | PFIZER INC. (US) | 2024-04-04 | — | — | US | disclosed |
| US-20230092163-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | NOVARTIS PHARMA AG (CH) | 2023-03-23 | — | — | US | disclosed |
| CN-115698021-A | Substituted thiazolopyridines, salts thereof and their use as herbicidal active substances | 拜耳公司 | 2023-02-03 | — | — | CN | disclosed |
| US-20230026271-A1 | Piperazine Compounds for Inhibiting CPS1 | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2023-01-26 | — | — | US | disclosed |
| EP-4061803-A1 | PIPERAZINE COMPOUNDS FOR INHIBITING CPS1 | Eisai R&D Management Co., Ltd. (JP) | 2022-09-28 | — | — | EP | disclosed |
| CN-114981247-A | Piperazine compounds for inhibiting CPS1 | 卫材R&D管理有限公司 | 2022-08-30 | — | — | CN | disclosed |
| EP-3983383-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | IFM Due, Inc. (US) | 2022-04-20 | — | — | EP | disclosed |
| WO-2021102300-A1 | PIPERAZINE COMPOUNDS FOR INHIBITING CPS1 | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2021-05-27 | — | — | WO | disclosed |
| WO-2020252240-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | IFM DUE, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
| WO-2020252240-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | IFM DUE, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
| US-7662824-B2 | Acylhydrazones as kinase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-16 | — | — | US | disclosed |
| US-7662824-B2 | Acylhydrazones as kinase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-16 | — | — | US | disclosed |
| US-7662824-B2 | Acylhydrazones as kinase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-16 | — | — | US | disclosed |
| US-20070066610-A1 | Acylhydrazones as kinase modulators | JANSSEN PHARMACEUTICAL, N.V. (BE) | 2007-03-22 | — | — | US | disclosed |
| US-20070066610-A1 | Acylhydrazones as kinase modulators | JANSSEN PHARMACEUTICAL, N.V. (BE) | 2007-03-22 | — | — | US | disclosed |
| US-20070066610-A1 | Acylhydrazones as kinase modulators | JANSSEN PHARMACEUTICAL, N.V. (BE) | 2007-03-22 | — | — | US | disclosed |
| WO-2006101937-A1 | ACYLHYDRAZONES AS KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230026271-A1 | Piperazine Compounds for Inhibiting CPS1 | CPS1, CPSF1, CPSF7 | AURKA 2319/4885TPX2 1382/4885ALDH1A1 1966/4885 |
| US-20070066610-A1 | Acylhydrazones as kinase modulators | MET, ERBB2, ERBB3 | AURKA 117/4885TPX2 1959/4885ALDH1A1 379/4885 |
| US-20230092163-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | STING1, CGAS, IRF3 | AURKA 3474/4885TPX2 109/4885ALDH1A1 4633/4885 |
| US-20240109915-A1 | NOVEL ACC INHIBITORS | CBR3, NAT1, ACACB | AURKA 815/4885TPX2 4583/4885ALDH1A1 2330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.