Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 3/20 | 0.49 |
| ▸ | SPR | P35270 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30829606 | 0.86 | ALDH1A1 (0.56) | KDM4EALDH1A1HSD17B10HPGDENPP2 | |
| SCHEMBL2173284 | 0.80 | NPC1 (0.55) | KDM4EALDH1A1HSD17B10HPGDPARP1 | |
| SCHEMBL16112245 | 0.77 | ALDH1A1 (0.56) | KDM4EALDH1A1HSD17B10HPGDSIRT2 | |
| SCHEMBL29583385 | 0.76 | ALDH1A1 (1.00) | KDM4EALDH1A1HSD17B10HPGDENPP2 | |
| SCHEMBL50542 | 0.76 | ALDH1A1 (1.00) | KDM4EALDH1A1HSD17B10HPGDENPP2 | |
| SCHEMBL4595294 | 0.76 | ALDH1A1 (1.00) | KDM4EALDH1A1HSD17B10HPGDENPP2 | |
| SCHEMBL3548319 | 0.75 | AURKA (0.63) | KDM4EALDH1A1HSD17B10HPGDENPP2 | |
| SCHEMBL30166619 | 0.75 | SPR (0.59) | KDM4EALDH1A1HSD17B10HPGDENPP2 | |
| SCHEMBL2001808 | 0.75 | SPR (0.59) | KDM4EALDH1A1HSD17B10HPGDENPP2 | |
| SCHEMBL6419348 | 0.74 | F7 (0.51) | KDM4EALDH1A1HSD17B10HPGDENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973164-B2 | Quinoline derivatives | ASTRAZENECA AB (SE) | 2011-07-05 | — | — | US | disclosed |
| US-20090076074-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | US | disclosed |
| EP-1994025-A1 | QUINOLINE DERIVATIVES | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007099326-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076074-A1 | QUINOLINE DERIVATIVES | RECQL, NQO2, CCNA1 | KDM4E 2492/4885ALDH1A1 887/4885HSD17B10 3699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.