SCHEMBL3549670

SCHEMBL3549670

COc1ccc(NC(=O)CN2C(=O)CSC2c2ccccc2)c(OC)c1

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.57
ALDH1A1 P00352 4/20 0.56
CYP1A2 P05177 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2C19 P33261 1/20 0.55
PKM P14618 1/20 0.54
MEN1 O00255 2/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
LMNA P02545 1/20 0.53
NPC1 O15118 2/20 0.53
RAB9A P51151 2/20 0.53
TP53 P04637 2/20 0.52
MAPT P10636 2/20 0.52
PTGS1 P23219 1/20 0.51
PTGS2 P35354 1/20 0.51
HPGD P15428 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3558328 0.76 NPC1 (0.51) KMT2AALDH1A1CYP2C9CYP2C19MEN1
SCHEMBL3549735 0.75 MEN1 (0.45) KMT2AALDH1A1CYP2C9CYP2C19MEN1
SCHEMBL3551478 0.75 MAPT (0.51) KMT2AALDH1A1CYP2C9CYP2C19MEN1
SCHEMBL13501913 0.73 MEN1 (0.56) KMT2AALDH1A1CYP2C9CYP2C19MEN1
SCHEMBL7204874 0.72 CYP2C9 (0.56) KMT2AALDH1A1CYP2C9CYP2C19MEN1
SCHEMBL3549397 0.72 TACR1 (0.47) KMT2AALDH1A1CYP2C9CYP2C19MEN1
SCHEMBL3546909 0.71 PTGS1 (0.58) KMT2AALDH1A1CYP2C9CYP2C19MEN1
SCHEMBL3549503 0.70 CYP2C9 (0.61) KMT2ACYP2C9CYP2C19MEN1SMN1; SMN2
SCHEMBL3555926 0.70 HPGD (0.53) KMT2AALDH1A1CYP2C9CYP2C19MEN1
SCHEMBL3547635 0.70 HPGD (0.53) KMT2AALDH1A1CYP2C9CYP2C19MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090143446-A1 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, METHODS OF MAKING, AND USES THEREOF UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2009-06-04 US claimed
EP-1692121-A1 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, METHODS OF MAKING, AND USES THEREOF University of Tennessee Research Foundation (US) 2006-08-23 EP claimed
US-20060040998-A1 Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2006-02-23 US claimed
WO-2005049591-A1 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, METHODS OF MAKING, AND USES THEREOF UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2005-06-02 WO claimed
US-7662842-B2 Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents Ohio State Univesity Research Foundation (US) 2010-02-16 US disclosed
US-20090143446-A1 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, METHODS OF MAKING, AND USES THEREOF UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2009-06-04 US disclosed
WO-2008128179-A1 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2008-10-23 WO disclosed
US-20080255213-A1 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2008-10-16 US disclosed
EP-1926487-A2 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS University of Tennessee Research Foundation (US) 2008-06-04 EP disclosed
WO-2008036067-A2 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2008-03-27 WO disclosed
US-7307093-B2 Cancer, selectivity to prostate cancer cell lines, ovarian cancer cells THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2007-12-11 US disclosed
US-20070155807-A1 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2007-07-05 US disclosed
EP-1723127-A2 ANALOGS EXHIBITING INHIBITION OF CELL PROLIFERATION, METHODS OF MAKING, AND USES THEREOF THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2006-11-22 EP disclosed
EP-1692121-A1 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, METHODS OF MAKING, AND USES THEREOF University of Tennessee Research Foundation (US) 2006-08-23 EP disclosed
US-20060040998-A1 Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2006-02-23 US disclosed
US-20060014740-A1 Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof US GOVERNMENT - SECRETARY FOR THE ARMY 2006-01-19 US disclosed
WO-2005086638-A2 ANALOGS EXHIBITING INHIBITION OF CELL PROLIFERATION, METHODS OF MAKING, AND USES THEREOF THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2005-09-22 WO disclosed
WO-2005049591-A1 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, METHODS OF MAKING, AND USES THEREOF UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2005-06-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090143446-A1 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, METHODS OF MAKING, AND USES THEREOF NAT1, AADAC, PPARG KMT2A 2012/4885ALDH1A1 23/4885CYP1A2 362/4885
US-20060014740-A1 Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof MKI67, MCL1, API5 KMT2A 2109/4885ALDH1A1 337/4885CYP1A2 2917/4885
US-20060040998-A1 Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof NAT1, AADAC, PPARG KMT2A 2012/4885ALDH1A1 23/4885CYP1A2 362/4885
US-20080255213-A1 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS SRM, SAT1, SMS KMT2A 557/4885ALDH1A1 185/4885CYP1A2 3912/4885
US-20070155807-A1 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS SRM, SAT1, SMS KMT2A 905/4885ALDH1A1 84/4885CYP1A2 3066/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.