Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT1A1 | P22309 | 4/20 | 0.65 |
| ▸ | MLNR | O43193 | 2/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.65 |
| ▸ | SLCO2B1 | O94956 | 2/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.65 |
| ▸ | CCKAR | P32238 | 2/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.65 |
| ▸ | GHSR | Q92847 | 2/20 | 0.65 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.65 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.65 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.64 |
| ▸ | CTSD | P07339 | 3/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3556305 | 0.95 | UGT1A1 (0.57) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL3551858 | 0.94 | UGT1A1 (0.67) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL3556351 | 0.93 | UGT1A1 (0.63) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL3551164 | 0.93 | UGT1A1 (0.65) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL3550949 | 0.91 | UGT1A1 (0.63) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL3557050 | 0.90 | CYP3A4 (0.70) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL3550635 | 0.89 | UGT1A1 (0.61) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL3551426 | 0.89 | CYP3A4 (0.59) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL3090647 | 0.89 | CYP3A4 (0.81) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL3556157 | 0.89 | CTSD (0.74) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697348-A1 | HIV PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 2006-09-06 | — | — | EP | claimed |
| US-20050159469-A1 | HIV protease inhibiting compounds | ABBVIE INC. | 2005-07-21 | — | — | US | claimed |
| WO-2005061487-A1 | HIV PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 2005-07-07 | — | — | WO | claimed |
| US-7696226-B2 | HIV protease inhibiting compounds | ABBOTT LABORATORIES (US) | 2010-04-13 | — | — | US | disclosed |
| US-20050159469-A1 | HIV protease inhibiting compounds | ABBVIE INC. | 2005-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159469-A1 | HIV protease inhibiting compounds | SERPINB1, HPN, DNPEP | UGT1A1 2307/4885MLNR 3723/4885NR1I2 3691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.