Vinblastine

Vinblastine

SCHEMBL3550

CC[C@]1(O)C[C@H]2C[N@](CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1.O=S(=O)(O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8

The experimentally established mechanism targets of Vinblastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A known ✓ P04350 6/20 1.00
TUBB known ✓ P07437 6/20 1.00
TUBA3C known ✓ P0DPH7 6/20 1.00
TUBA1B known ✓ P68363 6/20 1.00
TUBA4A known ✓ P68366 6/20 1.00
TUBB4B known ✓ P68371 6/20 1.00
TUBB3 known ✓ Q13509 6/20 1.00
TUBB2A known ✓ Q13885 6/20 1.00
TUBB8 known ✓ Q3ZCM7 6/20 1.00
TUBA3E known ✓ Q6PEY2 6/20 1.00
TUBA1A known ✓ Q71U36 6/20 1.00
TUBA1C known ✓ Q9BQE3 6/20 1.00
TUBB6 known ✓ Q9BUF5 6/20 1.00
TUBB2B known ✓ Q9BVA1 6/20 1.00
TUBB1 known ✓ Q9H4B7 6/20 1.00
MAPT P10636 8/20 1.00
MEN1 O00255 7/20 1.00
KMT2A Q03164 7/20 1.00
LMNA P02545 6/20 1.00
CYP3A4 P08684 6/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Vinblastine SCHEMBL2923482 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNATUBB4A
Vinblastine SCHEMBL3549 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNATUBB4A
Vinblastine SCHEMBL29357903 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNATUBB4A
Vinblastine SCHEMBL28131624 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNATUBB4A
Vinblastine SCHEMBL5535862 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNATUBB4A
Vinblastine SCHEMBL29594152 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNATUBB4A
Vinblastine SCHEMBL29554704 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNATUBB4A
Vinblastine SCHEMBL6340124 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNATUBB4A
Vinblastine SCHEMBL29879166 1.00 MAPT (1.00) MAPTMEN1KMT2ALMNATUBB4A
Vinblastine SCHEMBL5306718 0.99 MAPT (0.99) MAPTMEN1KMT2ALMNATUBB4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 31157 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735116-A2 ANTI-TRAILR2 ANTIGEN-BINDING PROTEINS AND USES THEREOF ODYSSEY THERAPEUTICS, INC. (US) 2026-05-06 EP claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
US-20260076872-A1 POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME SIO2 MEDICAL PRODUCTS LLC (US) 2026-03-19 US claimed
EP-4709378-A1 COMPOUNDS FOR NOS-RELATED CANCERS AND METHODS OF USE Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) 2026-03-18 EP claimed
US-20260069700-A1 BRUSH PRODRUGS AND USES THEREOF MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2026-03-12 US claimed
EP-4705491-A2 SMALL MOLECULE ENHANCERS FOR ADENO-ASSOCIATED VIRUS PRODUCTION Mirus Bio LLC (US) 2026-03-11 EP claimed
US-20260034101-A1 ANTIMITOTIC AMIDES FOR THE TREATMENT OF CANCER AND PROLIFERATIVE DISORDERS FROST BIOLOGIC INC (US) 2026-02-05 US claimed
US-12522572-B2 Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-01-13 US claimed
US-12478683-B2 Brush prodrugs and uses thereof MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2025-11-25 US claimed
WO-2025217110-A1 LIPID NANOPARTICLES FOR DRUG DELIVERY AND METHODS FOR MAKING AND USING THE SAME THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2025-10-16 WO claimed
WO-1989002734-A1 VASOCONSTRICTIVE SUBSTANCES IN COMBINATION WITH CYTOTOXIC AGENTS MATRIX PHARMACEUTICALS, INC. (US) 1989-04-06 WO claimed
EP-0295273-A1 METHOD OF ISOLATING VINBLASTINE HARBOR BRANCH OCEANOGRAPHIC INSTITUTION, INC. (US) 1988-12-21 EP claimed
US-4749787-A Process of isolating vinblastine from the plant catharanthis roseus HARBOR BRANCH OCEANOGRAPHIC INSTITUTION, INC. (US) 1988-06-07 US claimed
WO-1988003135-A2 METHOD OF ISOLATING VINBLASTINE HARBOR BRANCH OCEANOGRAPHIC INSTITUTION, INC. (US) 1988-05-05 WO claimed
US-4711782-A Prolonged release microcapsules and their production TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-12-08 US claimed
US-4565806-A Composition and method for rational treatment of cancer SETAELAE KAI M E 1986-01-21 US claimed
EP-0037289-B1 METHOD OF PREPARING A VINCA DIMER ELI LILLY AND COMPANY (US) 1984-08-01 EP claimed
US-4303584-A Method of preparing vincristine ELI LILLY AND COMPANY (US) 1981-12-01 US claimed
EP-0037289-A1 Method of preparing a vinca dimer ELI LILLY AND COMPANY (US) 1981-10-07 EP claimed
EP-0010964-A1 Ravidomycin, process of preparation and pharmaceutical compositions containing same AYERST, MCKENNA AND HARRISON INC. (CA) 1980-05-14 EP claimed