Known targets — ChEMBL curated mechanism
TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8
The experimentally established mechanism targets of Vinblastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A known ✓ | P04350 | 6/20 | 1.00 |
| ▸ | TUBB known ✓ | P07437 | 6/20 | 1.00 |
| ▸ | TUBA3C known ✓ | P0DPH7 | 6/20 | 1.00 |
| ▸ | TUBA1B known ✓ | P68363 | 6/20 | 1.00 |
| ▸ | TUBA4A known ✓ | P68366 | 6/20 | 1.00 |
| ▸ | TUBB4B known ✓ | P68371 | 6/20 | 1.00 |
| ▸ | TUBB3 known ✓ | Q13509 | 6/20 | 1.00 |
| ▸ | TUBB2A known ✓ | Q13885 | 6/20 | 1.00 |
| ▸ | TUBB8 known ✓ | Q3ZCM7 | 6/20 | 1.00 |
| ▸ | TUBA3E known ✓ | Q6PEY2 | 6/20 | 1.00 |
| ▸ | TUBA1A known ✓ | Q71U36 | 6/20 | 1.00 |
| ▸ | TUBA1C known ✓ | Q9BQE3 | 6/20 | 1.00 |
| ▸ | TUBB6 known ✓ | Q9BUF5 | 6/20 | 1.00 |
| ▸ | TUBB2B known ✓ | Q9BVA1 | 6/20 | 1.00 |
| ▸ | TUBB1 known ✓ | Q9H4B7 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vinblastine SCHEMBL2923482 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNATUBB4A | |
| Vinblastine SCHEMBL3549 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNATUBB4A | |
| Vinblastine SCHEMBL29357903 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNATUBB4A | |
| Vinblastine SCHEMBL28131624 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNATUBB4A | |
| Vinblastine SCHEMBL3550 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNATUBB4A | |
| Vinblastine SCHEMBL29594152 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNATUBB4A | |
| Vinblastine SCHEMBL29554704 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNATUBB4A | |
| Vinblastine SCHEMBL6340124 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNATUBB4A | |
| Vinblastine SCHEMBL29879166 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ALMNATUBB4A | |
| Vinblastine SCHEMBL5306718 | 0.99 | MAPT (0.99) | MAPTMEN1KMT2ALMNATUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817427-A2 | METHOD FOR DETERMINING GENOTOXICITY | F. Hoffmann-Roche AG (CH) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006056340-A2 | METHOD FOR DETERMINING GENOTOXICITY | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-01 | — | — | WO | disclosed |