Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA7 | P43166 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28509684 | 0.84 | DPP4 (0.39) | CA12CA1CA2CA7CA9 | |
| SCHEMBL28517699 | 0.84 | DPP4 (0.39) | CA12CA1CA2CA7CA9 | |
| SCHEMBL21366578 | 0.80 | CA12 (0.57) | CA12CA1CA2CA7CA9 | |
| SCHEMBL19618949 | 0.79 | CA12 (0.56) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2740732 | 0.79 | CA12 (0.56) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3164267 | 0.78 | CA12 (0.62) | CA12CA1CA2CA7CA9 | |
| SCHEMBL344331 | 0.77 | PDE4B (0.41) | GAAADRB2ADRB1ADRB3ADRA1D | |
| SCHEMBL14661699 | 0.76 | SLC6A2 (0.51) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1765701 | 0.76 | SLC6A2 (0.51) | CA12CA1CA2CA7CA9 | |
| SCHEMBL11901631 | 0.76 | SLC6A2 (0.51) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816542-B2 | Compounds and compositions as TPO mimetics | IRM LLC (BM) | 2010-10-19 | — | — | US | disclosed |
| US-7816542-B2 | Compounds and compositions as TPO mimetics | IRM LLC (BM) | 2010-10-19 | — | — | US | disclosed |
| US-7816542-B2 | Compounds and compositions as TPO mimetics | IRM LLC (BM) | 2010-10-19 | — | — | US | disclosed |
| CN-101282929-A | Compounds and compositions useful as TPO mimetics | IRM LLC (BM) | 2008-10-08 | — | — | CN | disclosed |
| US-20080194668-A1 | Compounds and Compositions as Tpo Mimetics | IRM LLC (BM) | 2008-08-14 | — | — | US | disclosed |
| US-20080194668-A1 | Compounds and Compositions as Tpo Mimetics | IRM LLC (BM) | 2008-08-14 | — | — | US | disclosed |
| US-20080194668-A1 | Compounds and Compositions as Tpo Mimetics | IRM LLC (BM) | 2008-08-14 | — | — | US | disclosed |
| EP-1915341-A2 | COMPOUNDS AND COMPOSITIONS AS TPO MIMETICS | IRM, LLC (BM) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007022269-A2 | COMPOUNDS AND COMPOSITIONS AS TPO MIMETICS | IRM LLC (BM) | 2007-02-22 | — | — | WO | disclosed |
| WO-2007022269-A2 | COMPOUNDS AND COMPOSITIONS AS TPO MIMETICS | IRM LLC (BM) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194668-A1 | Compounds and Compositions as Tpo Mimetics | MPL, TPO, THPO | CA12 4600/4885CA1 4857/4885CA2 4772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.