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TPO

Thyroid peroxidase · P07202 · TPO on Sugi Atlas →

2,674 patent compounds predicted against TPO, 1,790 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1536688 SCHEMBL1536688 0.53 20/20
SCHEMBL1536609 SCHEMBL1536609 0.57 19/20
SCHEMBL1536615 SCHEMBL1536615 0.62 18/20
SCHEMBL1536749 SCHEMBL1536749 0.61 18/20
SCHEMBL1536784 SCHEMBL1536784 0.60 18/20
SCHEMBL1536581 SCHEMBL1536581 0.56 18/20
SCHEMBL1536649 SCHEMBL1536649 0.54 18/20
SCHEMBL1536641 SCHEMBL1536641 0.54 18/20
SCHEMBL4257613 SCHEMBL4257613 0.53 18/20
SCHEMBL1536656 SCHEMBL1536656 0.53 18/20
SCHEMBL1536595 SCHEMBL1536595 0.52 18/20
SCHEMBL1536785 SCHEMBL1536785 0.50 18/20
SCHEMBL1536740 SCHEMBL1536740 0.49 18/20
SCHEMBL1536665 SCHEMBL1536665 0.47 18/20
SCHEMBL8223760 SCHEMBL8223760 0.47 18/20
SCHEMBL1536728 SCHEMBL1536728 0.61 17/20
SCHEMBL1536694 SCHEMBL1536694 0.57 17/20
Verdiperstat Verdiperstat (SCHEMBL1536607) 0.54 17/20
SCHEMBL1536753 SCHEMBL1536753 0.46 17/20
SCHEMBL1536690 SCHEMBL1536690 0.69 16/20

Clinical trials — most relevant to TPO by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment With Peginterferon Alfa-2a (40 KD) of Chronic Hepatitis B Patients, Who Have Failed Anti-viral Treatment PHASE4COMPLETED
Selenium Supplementation in Youths With Autoimmune Thyroiditis PHASE4COMPLETED
Effects of Different Treatment Schemes on the Regulation and Recurrence of Graves' Disease PHASE4RECRUITING
The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease PHASE2/PHASE3WITHDRAWN
LT4/LT3 Combination Therapy Versus LT4 Monotherapy in Patients with Autoimmune Hypothyroidism. PHASE3RECRUITING
Can Levothyroxine Treatment Reduce the Development of Cardio-metabolic Disorder in Subclinical Hypothyroidism? PHASE1/PHASE2UNKNOWN
Recurrent Pregnancy Loss and Thyroid Disease EARLY_PHASE1UNKNOWN
The Effect of Hydroxychloroquine Treatment in Hashimoto's Thyroiditis nanCOMPLETED
Selenium Supplementation in Pregnancy nanCOMPLETED
Correlation Vitamin D Level to Endocrine Autoimmune Toxicity Due to Immune Checkpoint Inhibitors nanRECRUITING
Role of Follicular T Cells in Hashimoto's Thyroiditis nanNOT_YET_RECRUITING
Oxidative Status in Children With Autoimmune Thyroiditis nanCOMPLETED
The Impact of Subclinical Hypothyroidism on Cardiovascular System nanUNKNOWN
Vitamin D, Hashimato's Thyroiditis and Thyroid Functions nanCOMPLETED
Thyroid Function Among Pediatric Patients With DM nanUNKNOWN
Natural History of Thyroid Function Disorders nanRECRUITING
A Study of Selenomethionine and Myo-inositol(SOLOWAYS_TM) in Patients With Autoimmune Thyroiditis Carrying the DIO2 Thr92Ala Polymorphism nanCOMPLETED
Dysregulation of the Soluble α-Klotho-FGF23 Axis in Hashimoto's Thyroiditis: A Case-Control Study nanNOT_YET_RECRUITING
Antithyroidal Antibodies With or Without Subclinical Hypothyroidism During Pregnancy in Infertile Women nanCOMPLETED
Effect of HCQ Combined With LT4 on LBR in Euthyroid Women With URPL and TPO-Ab nanRECRUITING
Non-immune Related Hypothyroidism in Iodine Sufficient Area nanCOMPLETED
Mechanistic Study of Subclinical Hypothyroidism In the Elderly nanCOMPLETED
Myo-inositol and Selenium in Indeterminate Thyroid Nodules (TIR3a) nanRECRUITING
Graves' Disease Induced by Epstein-Barr Virus Lytic Reactivation nanNOT_YET_RECRUITING
Thyroid Function Tests and Status of Thyroid Autoantibodies in Covid-19 Patients nanCOMPLETED
Corneal Tomographic Parameters in TGD nanCOMPLETED
Selenium Supplementation in Autoimmune Thyroiditis nanCOMPLETED
FGF-21 Levels and RMR in Children and Adolescents With Hashimoto's Thyroiditis (THYROMETABOL) nanCOMPLETED
Autoimmune Endocrine Disease Related Antibodies Before the Start of Immune Checkpoint Inhibitor Therapy nanRECRUITING
Study of Thyroid Status in Patients With IBD nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a TPO binder may also engage these)

ProteinNameSimilarity
P35419 — 1.000 P35419 →
P14650 — 0.998 P14650 →
P09933 — 0.995 P09933 →
Q8HYB7 — 0.992 Q8HYB7 →
A0A452E9Y6 — 0.992 A0A452E9Y6 →
LPO Lactoperoxidase 0.991 landscape →
Q5SW46 — 0.990 Q5SW46 →
Q8R481 — 0.986 Q8R481 →
P82600 — 0.986 P82600 →
Q9VEG6 — 0.985 Q9VEG6 →
Q7QH73 — 0.982 Q7QH73 →
O95672 — 0.976 O95672 →
Q9JHL3 — 0.974 Q9JHL3 →
F5HM55 — 0.974 F5HM55 →
Q3U435 — 0.974 Q3U435 →
Q8HZR1 — 0.973 Q8HZR1 →
Q9JMI0 — 0.972 Q9JMI0 →
Q9DBX3 — 0.972 Q9DBX3 →
O97554 — 0.971 O97554 →
Q96SM3 — 0.971 Q96SM3 →
P15101 — 0.971 P15101 →
Q1ENI8 — 0.971 Q1ENI8 →
A8WQH2 — 0.971 A8WQH2 →
INSRR Insulin receptor-related protein 0.971 landscape →
O62664 — 0.971 O62664 →
Q9Y6F9 — 0.970 Q9Y6F9 →
O88917 — 0.970 O88917 →
P0DPE2 — 0.970 P0DPE2 →
MMP24 Matrix metalloproteinase-24 0.970 landscape →
A0A1Y9G8H0 — 0.970 A0A1Y9G8H0 →