Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 9/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 8/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 8/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3544001 | 0.85 | KDM4E (0.37) | KDM4EALDH1A1LMNAGAAHPGD | |
| SCHEMBL30135929 | 0.84 | KDM4E (0.36) | KDM4EALDH1A1LMNAGAAHPGD | |
| SCHEMBL1203575 | 0.84 | KDM4E (0.36) | KDM4EALDH1A1LMNAGAAHPGD | |
| SCHEMBL16473281 | 0.84 | TTK (0.37) | KDM4EALDH1A1LMNAGAAHPGD | |
| SCHEMBL3666481 | 0.81 | KDM4E (0.36) | KDM4EALDH1A1LMNAGAAHPGD | |
| SCHEMBL17706073 | 0.77 | MTOR (0.36) | KDM4EALDH1A1LMNAGAAHPGD | |
| SCHEMBL1203446 | 0.76 | GSK3A (0.45) | PIK3CA | |
| SCHEMBL3539781 | 0.74 | PLK1 (0.52) | KDM4EALDH1A1LMNAGAAHPGD | |
| SCHEMBL15498579 | 0.74 | GSK3B (0.59) | — | |
| SCHEMBL13881269 | 0.74 | OPRM1 (0.40) | KDM4EALDH1A1LMNAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709471-B2 | Compounds | ASTRAZENECA AB (SE) | 2010-05-04 | — | — | US | disclosed |
| US-20080009482-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009482-A1 | NOVEL COMPOUNDS | CYP11B2, CYP11B1, CYP46A1 | KDM4E 3977/4885ALDH1A1 422/4885LMNA 1996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.