Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3545517 | 0.83 | PDK1 (0.39) | MTORPDK1PDK2PDK3PIK3CA | |
| SCHEMBL28003161 | 0.82 | MTOR (0.41) | MTORPDK1PDK2PDK3PIK3CA | |
| SCHEMBL13634284 | 0.81 | PDK1 (0.40) | MTORPDK1PDK2PDK3PIK3CA | |
| SCHEMBL13634272 | 0.81 | PDK1 (0.40) | MTORPDK1PDK2PDK3PIK3CA | |
| SCHEMBL3435910 | 0.81 | PDK1 (0.38) | MTORPDK1PDK2PDK3PIK3CA | |
| SCHEMBL13634351 | 0.81 | PDK1 (0.38) | MTORPDK1PDK2PDK3PIK3CA | |
| SCHEMBL13162772 | 0.77 | MTOR (0.40) | MTORPDK1PDK2PDK3PIK3CA | |
| SCHEMBL13162767 | 0.77 | MTOR (0.40) | MTORPDK1PDK2PDK3PIK3CA | |
| SCHEMBL3435190 | 0.77 | MTOR (0.36) | MTORPDK1PDK2PDK3PIK3CA | |
| SCHEMBL14000051 | 0.77 | GAA (0.42) | MAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163746-B2 | Azolecarboxamide derivative | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | GPR17, NTRK1, TRPV1 | MTOR 1596/4885PDK1 1088/4885PDK2 1250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.