Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.68 |
| ▸ | IGF1R | P08069 | 2/20 | 0.61 |
| ▸ | AURKA | O14965 | 4/20 | 0.58 |
| ▸ | CDK7 | P50613 | 4/20 | 0.58 |
| ▸ | CDK9 | P50750 | 4/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.58 |
| ▸ | CDK4 | P11802 | 3/20 | 0.58 |
| ▸ | CDK1 | P06493 | 3/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.56 |
| ▸ | WEE1 | P30291 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 8/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448559 | 0.83 | CDK2 (0.73) | CDK2CDK1SYKKCNH2 | |
| SCHEMBL3549598 | 0.82 | CDK2 (0.83) | CDK2IGF1RAURKACDK7CDK9 | |
| SCHEMBL1447567 | 0.82 | CDK2 (0.72) | CDK2CDK4CDK1JAK2BTK | |
| SCHEMBL1447265 | 0.80 | CDK2 (0.69) | CDK2CDK1TBK1SYKKCNH2 | |
| SCHEMBL1448088 | 0.78 | CDK2 (0.66) | CDK2CDK1TBK1SYKKCNH2 | |
| SCHEMBL1448568 | 0.75 | CDK2 (0.64) | CDK2CDK1KCNH2 | |
| SCHEMBL3548656 | 0.75 | CDK2 (1.00) | CDK2CDK7CDK9CDK4CDK1 | |
| SCHEMBL4026694 | 0.75 | CDK2 (0.64) | CDK2CDK7CDK9CDK4CDK1 | |
| SCHEMBL3551129 | 0.74 | CDK2 (0.85) | CDK2CDK7CDK9CDK4CDK1 | |
| SCHEMBL4393252 | 0.74 | JAK2 (0.75) | FLT3JAK2PRKD3RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655652-B2 | 2-{4-[4-(2-hydroxyacetyl)piperazin-1-yl]anilino}-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-5-fluoropyrimidine hydrochloride; cell cycle inhibitory; rheumatoid arthritis | ASTRAZENECA AB (SE) | 2010-02-02 | — | — | US | disclosed |
| US-20070161615-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161615-A1 | Chemical compounds | MKI67, PCNA, CCNI | CDK2 84/4885IGF1R 3080/4885AURKA 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.