Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234641 | 0.86 | SLC6A3 (0.55) | SLC6A3SLC6A4GRM5ALDH1A1AXL | |
| SCHEMBL29694130 | 0.86 | SLC6A3 (0.55) | SLC6A3SLC6A4GRM5ALDH1A1AXL | |
| SCHEMBL28677127 | 0.83 | KDM4E (0.47) | SLC6A3SLC6A4GRM5ALDH1A1KDM4E | |
| SCHEMBL3555744 | 0.82 | NAPRT (0.50) | GRM5ALDH1A1TDP1KDM4EKMT2A | |
| SCHEMBL19923176 | 0.81 | SLC6A3 (0.59) | SLC6A3SLC6A4ALDH1A1KDM4EPOLB | |
| SCHEMBL30956563 | 0.79 | KMO (0.48) | SLC6A3SLC6A4ALDH1A1KDM4EPOLB | |
| SCHEMBL13824012 | 0.77 | SLC6A3 (0.64) | SLC6A3SLC6A4ALDH1A1KDM4EPOLB | |
| SCHEMBL28199188 | 0.77 | GRM5 (0.50) | SLC6A3SLC6A4GRM5ALDH1A1AXL | |
| SCHEMBL27568450 | 0.77 | TDP1 (0.51) | SLC6A3GRM5ALDH1A1AXLTDP1 | |
| SCHEMBL29664560 | 0.76 | TDP1 (0.54) | GRM5ALDH1A1AXLTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963312-B1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2014-07-02 | — | — | EP | disclosed |
| US-7838676-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-11-23 | — | — | US | disclosed |
| EP-1963312-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| US-20070173521-A1 | Beta-secretase modulators and methods of use | AMGEN INC. | 2007-07-26 | — | — | US | disclosed |
| WO-2007061930-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173521-A1 | Beta-secretase modulators and methods of use | BACE1, BACE2, APP | SLC6A3 4711/4885SLC6A4 4720/4885GRM5 1069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.