Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 7/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.34 |
| ▸ | HTR1D | P28221 | 4/20 | 0.33 |
| ▸ | HTR1B | P28222 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | IRAK2 | O43187 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3553017 | 0.99 | CYP2D6 (0.41) | CYP2D6PLATHTR1FPIK3CAMTOR | |
| SCHEMBL3553121 | 0.90 | CYP2D6 (0.44) | CYP2D6HTR1FHTR1DHTR1BHTR2C | |
| SCHEMBL3547115 | 0.90 | HTR1F (0.40) | HTR1FHTR1DHTR1BHTR2CHTR1A | |
| Hydrochloric Acid SCHEMBL3545956 | 0.90 | HTR1F (0.39) | HTR1FHTR1DHTR1BHTR2CHTR1A | |
| Hydrochloric Acid SCHEMBL3549547 | 0.90 | CYP2D6 (0.44) | CYP2D6HTR1FHTR1DHTR1BHTR2C | |
| SCHEMBL3548945 | 0.83 | HTR1F (0.47) | CYP2D6HTR1FHTR1DHTR1BHTR2C | |
| Hydrochloric Acid SCHEMBL3542250 | 0.82 | HTR1F (0.46) | CYP2D6HTR1FHTR1DHTR1BHTR2C | |
| SCHEMBL3548802 | 0.82 | CYP2D6 (0.42) | CYP2D6HTR1DHTR1BL3MBTL3 | |
| SCHEMBL6844233 | 0.81 | HTR1F (0.37) | PLATHTR1FHTR1DHTR1BHTR2C | |
| Hydrochloric Acid SCHEMBL3543341 | 0.81 | CYP2D6 (0.42) | CYP2D6HTR1DHTR1BL3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741343-B2 | 6H-oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2010-06-22 | — | — | US | disclosed |
| US-20080051394-A1 | 6H-Oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | SCHIEMANN KAI | 2008-02-28 | — | — | US | disclosed |
| US-7291633-B2 | 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2007-11-06 | — | — | US | disclosed |
| US-20050101649-A1 | 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2005-05-12 | — | — | US | disclosed |
| EP-1392699-B1 | 6H-OXAZOLO 4,5-E]INDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GMBH (DE) | 2005-03-16 | — | — | EP | disclosed |
| EP-1392699-A1 | 6H-OXAZOLO 4,5-E]INDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GmbH (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002088139-A1 | 6H-OXAZOLO[4,5-E]INDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GMBH (DE) | 2002-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051394-A1 | 6H-Oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | CHRM1, CHRNA5, CHRNA4 | CYP2D6 2008/4885PLAT 1720/4885HTR1F 53/4885 |
| US-20050101649-A1 | 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | CHRM1, CHRNA5, CHRNA4 | CYP2D6 2220/4885PLAT 1484/4885HTR1F 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.