⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902535 | 1.00 | — | — | |
| SCHEMBL6196835 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL6201103 | 0.98 | ARG1 (0.36) | — | |
| Bromide SCHEMBL10467943 | 0.98 | ARG1 (0.36) | — | |
| Butanone SCHEMBL11500297 | 0.87 | ALDH1A1 (0.36) | — | |
| SCHEMBL29974391 | 0.79 | — | — | |
| SCHEMBL1848836 | 0.76 | NPSR1 (0.39) | — | |
| SCHEMBL11459581 | 0.71 | — | — | |
| SCHEMBL774037 | 0.70 | ARG1 (0.39) | — | |
| SCHEMBL22631470 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109952299-B | Fluorohydroxyproline derivatives for the preparation of protein degradation targeting chimeras | 邓迪大学 | 2023-04-18 | — | — | CN | disclosed |
| EP-3268363-B1 | DERIVATIVES OF 1-[(CYCLOPENTYL OR 2-PYRROLIDINYL)CARBONYLAMINOMETHYL]-4-(1,3-THIAZOL-5-YL) BENZENE WHICH ARE USEFUL FOR THE TREATMENT OF PROLIFERATIVE, AUTOIMMUNE OR INFLAMMATORY DISEASES | THE UNIV OF DUNDEE (GB) | 2022-05-04 | — | — | EP | disclosed |
| US-11234988-B2 | Fluorohydroxyproline derivatives useful in the preparation of proteolysis targeted chimeras | UNIVERSITY OF DUNDEE (GB) | 2022-02-01 | — | — | US | disclosed |
| US-11179373-B2 | Derivatives of 1-[(cyclopentyl or 2-pyrrolidinyl)carbonylaminomethyl]-4-(l,3-thiazol-5-yl) benzene which are useful for the treatment of proliferative, autoimmune or inflammatory diseases | UNIVERSITY OF DUNDEE (GB) | 2021-11-23 | — | — | US | disclosed |
| US-20190255066-A1 | FLUOROHYDROXYPROLINE DERIVATIVES USEFUL IN THE PREPARATION OF PROTEOLYSIS TARGETED CHIMERAS | UNIVERSITY OF DUNDEE (GB) | 2019-08-22 | — | — | US | disclosed |
| EP-3512844-A1 | FLUOROHYDROXYPROLINE DERIVATIVES USEFUL IN THE PREPARATION OF PROTEOLYSIS TARGETED CHIMERAS | University Of Dundee (GB) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018051107-A1 | FLUOROHYDROXYPROLINE DERIVATIVES USEFUL IN THE PREPARATION OF PROTEOLYSIS TARGETED CHIMERAS | UNIVERSITY OF DUNDEE (GB) | 2018-03-22 | — | — | WO | disclosed |
| US-20180050021-A1 | Derivatives of 1-[(cyclopentyl or 2-pyrrolidinyl)carbonylaminomethyl]-4-(1,3-Thiazol-5-yl) benzene which are Useful for the Treatment of Proliferative, Autoimmune or Inflammatory Diseases | UNIVERSITY OF DUNDEE (GB) | 2018-02-22 | — | — | US | disclosed |
| EP-3268363-A1 | DERIVATIVES OF 1-[(CYCLOPENTYL OR 2-PYRROLIDINYL)CARBONYLAMINOMETHYL]-4-(1,3-THIAZOL-5-YL) BENZENE WHICH ARE USEFUL FOR THE TREATMENT OF PROLIFERATIVE, AUTOIMMUNE OR INFLAMMATORY DISEASES | The University of Dundee (GB) | 2018-01-17 | — | — | EP | disclosed |
| WO-2016146985-A1 | DERIVATIVES OF 1-[(CYCLOPENTYL OR 2-PYRROLIDINYL)CARBONYLAMINOMETHYL]-4-(1,3-THIAZOL-5-YL) BENZENE WHICH ARE USEFUL FOR THE TREATMENT OF PROLIFERATIVE, AUTOIMMUNE OR INFLAMMATORY DISEASES | UNIVERSITY OF DUNDEE (GB) | 2016-09-22 | — | — | WO | disclosed |
| US-7691843-B2 | N-hydroxyamide derivatives possessing antibacterial activity | PFIZER INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-20080058304-A1 | N-hydroxyamide derivatives possessing antibacterial activity | VICURON HOLDINGS LLC | 2008-03-06 | — | — | US | disclosed |
| EP-1539744-A4 | N-HYDROXYAMIDE DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY | VICURON PHARM INC (US) | 2007-06-06 | — | — | EP | disclosed |
| EP-1539744-A2 | N-HYDROXYAMIDE DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY | Vicuron Pharmaceuticals, Inc. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004007444-A2 | N-HYDROXYAMIDE DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY | VICURON PHARMACEUTICALS, INC. (US) | 2004-01-22 | — | — | WO | disclosed |