Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.67 |
| ▸ | DRD4 | P21917 | 3/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.62 |
| ▸ | DRD3 | P35462 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.58 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2979953 | 0.92 | SIGMAR1 (0.60) | SIGMAR1DRD4DRD2DRD3KMT2A | |
| SCHEMBL2425554 | 0.92 | SIGMAR1 (0.78) | SIGMAR1DRD4DRD2DRD3KMT2A | |
| Hydrochloric Acid SCHEMBL21410212 | 0.90 | SIGMAR1 (0.76) | SIGMAR1DRD4DRD2DRD3KMT2A | |
| SCHEMBL4298575 | 0.86 | SIGMAR1 (0.70) | SIGMAR1DRD4DRD2DRD3KMT2A | |
| SCHEMBL3946017 | 0.83 | MCHR1 (0.70) | SIGMAR1DRD4DRD2DRD3KMT2A | |
| SCHEMBL3892168 | 0.83 | KMT2A (0.61) | SIGMAR1DRD4DRD2DRD3KMT2A | |
| SCHEMBL3164487 | 0.83 | SIGMAR1 (0.74) | SIGMAR1DRD4DRD2DRD3KMT2A | |
| SCHEMBL20183285 | 0.83 | DRD4 (0.70) | SIGMAR1DRD4DRD2DRD3KMT2A | |
| SCHEMBL19614234 | 0.83 | DRD4 (0.70) | SIGMAR1DRD4DRD2DRD3KMT2A | |
| SCHEMBL17961749 | 0.83 | DRD4 (0.70) | SIGMAR1DRD4DRD2DRD3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858622-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-28 | — | — | US | disclosed |
| US-20100004228-A1 | SELECTED CGRP ANTAGONISTS, PROCESSES FOR PREPARING THEM AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004228-A1 | SELECTED CGRP ANTAGONISTS, PROCESSES FOR PREPARING THEM AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | CALCRL, CALCR, CALCA | SIGMAR1 592/4885DRD4 329/4885DRD2 241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.