Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | PKLR | P30613 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CRHBP | P24387 | 2/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30216657 | 0.82 | MAP3K14 (0.45) | MAP3K14OPRL1ITGB2ICAM1ITGAL | |
| SCHEMBL1266237 | 0.82 | MAP3K14 (0.45) | MAP3K14OPRL1ITGB2ICAM1ITGAL | |
| SCHEMBL26962672 | 0.82 | MAP3K14 (0.45) | MAP3K14OPRL1ITGB2ICAM1ITGAL | |
| Hydrochloric Acid SCHEMBL26962795 | 0.81 | MAP3K14 (0.44) | MAP3K14OPRL1ITGB2ICAM1ITGAL | |
| SCHEMBL3267497 | 0.80 | MAP3K14 (0.64) | MAP3K14OPRL1ITGB2ICAM1ITGAL | |
| SCHEMBL3561436 | 0.79 | MAP3K14 (0.67) | MAP3K14ITGB2ICAM1ITGALSMN1; SMN2 | |
| SCHEMBL24727111 | 0.78 | MAP3K14 (0.42) | MAP3K14OPRL1JAK2JAK3SMN1; SMN2 | |
| SCHEMBL3562075 | 0.75 | ADRA2A (0.32) | MAP3K14ADRA2A | |
| SCHEMBL29960701 | 0.75 | MAP3K14 (0.45) | MAP3K14ABCB1HTR2CTP53 | |
| SCHEMBL27736666 | 0.75 | MAP3K14 (0.41) | MAP3K14OPRL1ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718809-B2 | Chromane substituted benzimidazole derivatives as acid pump antagonists | RAQUALIA PHARMA INC. (JP) | 2010-05-18 | — | — | US | disclosed |
| EP-1893197-B1 | CHROMANE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ACID PUMP ANTAGONISTS | RAQUALIA PHARMA INC (JP) | 2009-09-09 | — | — | EP | disclosed |
| EP-1996589-A1 | CHROMANE DERIVATIVES | RaQualia Pharma Inc (JP) | 2008-12-03 | — | — | EP | disclosed |
| US-20080214519-A1 | Chromane Substituted Benzimidazole Derivatives as Acid Pump Antagonists | RAQUALIA PHARMA INC. (JP) | 2008-09-04 | — | — | US | disclosed |
| EP-1893197-A1 | CHROMANE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ACID PUMP ANTAGONISTS | Pfizer, Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2007107827-A1 | CHROMANE DERIVATIVES | RAQUALIA PHARMA INC. (JP) | 2007-09-27 | — | — | WO | disclosed |
| US-20070219237-A1 | Chromane Derivatives | PFIZER INC | 2007-09-20 | — | — | US | disclosed |
| WO-2006134460-A1 | CHROMANE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ACID PUMP ANTAGONISTS | PFIZER JAPAN INC. (JP) | 2006-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219237-A1 | Chromane Derivatives | HRH2, HRH1, CHRM1 | MAP3K14 2992/4885OPRL1 106/4885ITGB2 3033/4885 |
| US-20080214519-A1 | Chromane Substituted Benzimidazole Derivatives as Acid Pump Antagonists | HRH2, HRH4, HRH1 | MAP3K14 2415/4885OPRL1 108/4885ITGB2 2533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.