Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732629 | 0.82 | ADRA2A (0.32) | ADRA2A | |
| Hydrochloric Acid SCHEMBL1162711 | 0.81 | ADRA2A (0.31) | ADRA2A | |
| SCHEMBL29846494 | 0.80 | MAP3K14 (0.42) | ADRA2AMAP3K14 | |
| SCHEMBL29809288 | 0.80 | MAP3K14 (0.42) | ADRA2AMAP3K14 | |
| SCHEMBL28575567 | 0.80 | MAP3K14 (0.42) | ADRA2AMAP3K14 | |
| SCHEMBL23832310 | 0.80 | MAP3K14 (0.42) | ADRA2AMAP3K14 | |
| SCHEMBL3269304 | 0.80 | MAP3K14 (0.42) | ADRA2AMAP3K14 | |
| SCHEMBL29848515 | 0.80 | MAP3K14 (0.42) | ADRA2AMAP3K14 | |
| SCHEMBL28418993 | 0.79 | ADRA2A (0.32) | ADRA2AMAP3K14 | |
| SCHEMBL3553150 | 0.75 | MAP3K14 (0.45) | ADRA2AMAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718809-B2 | Chromane substituted benzimidazole derivatives as acid pump antagonists | RAQUALIA PHARMA INC. (JP) | 2010-05-18 | — | — | US | disclosed |
| EP-1893197-B1 | CHROMANE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ACID PUMP ANTAGONISTS | RAQUALIA PHARMA INC (JP) | 2009-09-09 | — | — | EP | disclosed |
| CN-101410396-A | Chromane derivatives | RAQUALIA PHARMA INC (JP) | 2009-04-15 | — | — | CN | disclosed |
| WO-2008151927-A2 | 6-N-SUBSTITUTED BENZ IMIDAZOLE DERIVATIVES AS ACID PUMP ANTAGONISTS | NYCOMED GMBH (DE) | 2008-12-18 | — | — | WO | disclosed |
| EP-1996589-A1 | CHROMANE DERIVATIVES | RaQualia Pharma Inc (JP) | 2008-12-03 | — | — | EP | disclosed |
| US-20080214519-A1 | Chromane Substituted Benzimidazole Derivatives as Acid Pump Antagonists | RAQUALIA PHARMA INC. (JP) | 2008-09-04 | — | — | US | disclosed |
| EP-1893197-A1 | CHROMANE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ACID PUMP ANTAGONISTS | Pfizer, Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2007107827-A1 | CHROMANE DERIVATIVES | RAQUALIA PHARMA INC. (JP) | 2007-09-27 | — | — | WO | disclosed |
| US-20070219237-A1 | Chromane Derivatives | PFIZER INC | 2007-09-20 | — | — | US | disclosed |
| WO-2006134460-A1 | CHROMANE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ACID PUMP ANTAGONISTS | PFIZER JAPAN INC. (JP) | 2006-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219237-A1 | Chromane Derivatives | HRH2, HRH1, CHRM1 | ADRA2A 397/4885MAP3K14 2992/4885 |
| US-20080214519-A1 | Chromane Substituted Benzimidazole Derivatives as Acid Pump Antagonists | HRH2, HRH4, HRH1 | ADRA2A 310/4885MAP3K14 2415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.