Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3558616 | 0.80 | KMT2A (0.46) | TSHRCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3552219 | 0.80 | RXRA (0.40) | GRM5KCNA5DYRK1ACHRNB2CHRNA4 | |
| SCHEMBL3549141 | 0.79 | CHRM5 (0.45) | DYRK1ATSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27549059 | 0.78 | KCNA5 (0.51) | GRM5KCNA5CYP1A2CYP3A4CHRNB2 | |
| SCHEMBL27628431 | 0.78 | TSHR (0.53) | KCNA5TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3409401 | 0.78 | KCNA5 (0.49) | GRM5KCNA5CYP1A2CYP3A4CHRNB2 | |
| Hydrochloric Acid SCHEMBL4024971 | 0.76 | KCNA5 (0.47) | GRM5KCNA5CYP1A2CYP3A4CHRNB2 | |
| SCHEMBL5075470 | 0.72 | KCNA5 (0.50) | GRM5KCNA5CYP1A2CYP3A4MAPK1 | |
| SCHEMBL9878999 | 0.71 | LMNA (0.50) | TSHRCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8896696 | 0.71 | DYRK1A (0.36) | GRM5KCNA5DYRK1ATSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696204-B2 | Pharmaceutical compounds | LUDWIG INSTITUTE FOR CANCER RESEARCH (CH) | 2010-04-13 | — | — | US | disclosed |
| US-20090042884-A1 | Pharmaceutical Compounds | F.HOFFMANN-LA ROCHE AG (CH) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042884-A1 | Pharmaceutical Compounds | PIK3CA, JAK1, PIK3R1 | GRM5 1206/4885KCNA5 3815/4885DYRK1A 1498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.