Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 4/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3551265 | 0.81 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11IDH1 | |
| SCHEMBL3548331 | 0.81 | LMNA (0.45) | KDM4EMEN1NPC1ALDH1A1LMNA | |
| SCHEMBL4496950 | 0.81 | NPC1 (0.51) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL4476709 | 0.78 | PRKCD (0.49) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL3556311 | 0.73 | DYRK1A (0.56) | MAPK14MAPK13MAPK12MAPK11FLT3 | |
| SCHEMBL3551857 | 0.73 | MAPK13 (0.49) | MAPK14MAPK13MAPK12MAPK11IDH1 | |
| SCHEMBL3548953 | 0.71 | FLT3 (0.49) | MAPK14MAPK13MAPK12MAPK11IDH1 | |
| SCHEMBL3555802 | 0.71 | FLT3 (0.54) | MAPK14MAPK13MAPK12MAPK11FLT3 | |
| SCHEMBL3554558 | 0.70 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11IDH1 | |
| SCHEMBL19191951 | 0.70 | IDH1 (0.82) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718801-B2 | Substituted imidazole derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-05-18 | — | — | US | disclosed |
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | MSD K.K. (JP) | 2008-03-20 | — | — | US | disclosed |
| EP-1790650-A1 | NOVEL SUBSTITUTED IMIDAZOLE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | PLK1, CDK1, CDK11A | MAPK14 680/4885MAPK13 678/4885MAPK12 957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.