Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydroxyprogesterone Caproate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 3/20 | 0.78 |
| ▸ | LMNA | P02545 | 7/20 | 0.78 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.78 |
| ▸ | MEN1 | O00255 | 3/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.78 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.78 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.78 |
| ▸ | HPGD | P15428 | 1/20 | 0.78 |
| ▸ | MLNR | O43193 | 1/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.78 |
| ▸ | HTT | P42858 | 1/20 | 0.78 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.78 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.63 |
| ▸ | SHBG | P04278 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyprogesterone Caproate SCHEMBL1445611 | 0.94 | LMNA (0.81) | LMNANR3C1CYP3A4KMT2ASMN1; SMN2 | |
| Hydroxyprogesterone Caproate SCHEMBL8817313 | 0.92 | LMNA (0.79) | LMNANR3C1CYP3A4KMT2ASMN1; SMN2 | |
| SCHEMBL3973882 | 0.90 | LMNA (0.75) | LMNANR3C1CYP3A4KMT2ASMN1; SMN2 | |
| Hydroxyprogesterone Caproate SCHEMBL5330 | 0.88 | LMNA (1.00) | LMNANR3C1CYP3A4KMT2ASMN1; SMN2 | |
| Hydroxyprogesterone Caproate SCHEMBL21497316 | 0.88 | LMNA (1.00) | LMNANR3C1CYP3A4KMT2ASMN1; SMN2 | |
| Hydroxyprogesterone Caproate SCHEMBL508890 | 0.88 | LMNA (1.00) | LMNANR3C1CYP3A4KMT2ASMN1; SMN2 | |
| Hydroxyprogesterone Caproate SCHEMBL16812894 | 0.88 | LMNA (1.00) | LMNANR3C1CYP3A4KMT2ASMN1; SMN2 | |
| Hydroxyprogesterone Caproate SCHEMBL17517045 | 0.88 | LMNA (1.00) | LMNANR3C1CYP3A4KMT2ASMN1; SMN2 | |
| Hydroxyprogesterone Caproate SCHEMBL94788 | 0.88 | LMNA (1.00) | LMNANR3C1CYP3A4KMT2ASMN1; SMN2 | |
| Hydroxyprogesterone Caproate SCHEMBL14649335 | 0.88 | LMNA (1.00) | LMNANR3C1CYP3A4KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732436-B2 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2010-06-08 | — | — | US | disclosed |
| US-7385055-B2 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2008-06-10 | — | — | US | disclosed |
| US-20060293305-A1 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2006-12-28 | — | — | US | disclosed |
| US-20040235820-A1 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235820-A1 | Preparation of hymenialdisine derivatives and use thereof | NFKBIA, IKBKG, GSK3B | PGR 3520/4885LMNA 1639/4885NR3C1 3009/4885 |
| US-20060293305-A1 | Preparation of hymenialdisine derivatives and use thereof | IDO2, CHEK2, NFKBIA | PGR 3802/4885LMNA 1641/4885NR3C1 3796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.