Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.56 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1004476 | 0.93 | TNF (0.63) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1004093 | 0.93 | TNF (0.63) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12938925 | 0.92 | TNF (0.64) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL354741 | 0.90 | TNF (0.53) | TNFSLC6A4SLC6A2HRH1PSEN1 | |
| SCHEMBL354801 | 0.90 | RXFP1 (0.55) | TNFSLC6A4SLC6A2HRH1PSEN1 | |
| SCHEMBL355330 | 0.90 | TNF (0.53) | TNFSLC6A4SLC6A2HRH1PSEN1 | |
| SCHEMBL355062 | 0.89 | PSEN1 (0.54) | TNFSLC6A4SLC6A2HRH1PSEN1 | |
| SCHEMBL352528 | 0.86 | MAPT (0.51) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14266804 | 0.83 | SMN1; SMN2 (0.47) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL353749 | 0.83 | SMN1; SMN2 (0.49) | TNFPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1649283-B1 | METHOD FOR MEASURING AROMATASE ACTIVITY | GE HEALTHCARE UK LTD (GB) | 2014-06-18 | — | — | EP | disclosed |
| US-8334387-B2 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2012-12-18 | — | — | US | disclosed |
| US-8334387-B2 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2012-12-18 | — | — | US | disclosed |
| US-8334387-B2 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2012-12-18 | — | — | US | disclosed |
| US-20120015373-A1 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | GE HEALTHCARE UK LIMITED (GB) | 2012-01-19 | — | — | US | disclosed |
| US-8034558-B2 | Incubating dye of given formula with biological material, measuring fluorescence lifetime; lectins/glycoproteins, biotin/streptavidin, DNA/RNA | GE HEALTHCARE UK LIMITED (GB) | 2011-10-11 | — | — | US | disclosed |
| US-20110014641-A1 | METHOD FOR MEASURING AROMATASE ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2011-01-20 | — | — | US | disclosed |
| US-20110014641-A1 | METHOD FOR MEASURING AROMATASE ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2011-01-20 | — | — | US | disclosed |
| US-20110014641-A1 | METHOD FOR MEASURING AROMATASE ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2011-01-20 | — | — | US | disclosed |
| US-7829714-B2 | Method for measuring aromatase activity | GE HEALTHCARE LIMITED (GB) | 2010-11-09 | — | — | US | disclosed |
| US-7829714-B2 | Method for measuring aromatase activity | GE HEALTHCARE LIMITED (GB) | 2010-11-09 | — | — | US | disclosed |
| US-20080139788-A1 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | GE HEALTHCARE UK LIMITED (GB) | 2008-06-12 | — | — | US | disclosed |
| US-20070184429-A1 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| US-20070184429-A1 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| US-20070184429-A1 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| EP-1649283-A2 | METHOD FOR MEASURING AROMATASE ACTIVITY | GE Healthcare UK Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012901-A2 | METHOD FOR MEASURING AROMATASE ACTIVITY | AMERSHAM BIOSCIENCES UK LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |
| US-20040191792-A1 | Acridone derivatives as labels for fluorescence detection of target materials | GE HEALTHCARE UK LIMITED (GB) | 2004-09-30 | — | — | US | disclosed |
| EP-1392776-A2 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | Amersham Biosciences UK Limited (GB) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002099424-A2 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | AMERSHAM BIOSCIENCES UK LIMITED (GB) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139788-A1 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | ACR, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ARSA | TNF 4339/4885SLC6A4 622/4885SLC6A2 1772/4885 |
| US-20110014641-A1 | METHOD FOR MEASURING AROMATASE ACTIVITY | CYP19A1, CYP17A1, CYP21A2 | TNF 3471/4885SLC6A4 1780/4885SLC6A2 2100/4885 |
| US-20040191792-A1 | Acridone derivatives as labels for fluorescence detection of target materials | ACR, ARSA, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | TNF 4012/4885SLC6A4 637/4885SLC6A2 2468/4885 |
| US-20070184429-A1 | Method for measuring aromatase activity | CYP19A1, CYP17A1, CYP21A2 | TNF 3471/4885SLC6A4 1780/4885SLC6A2 2100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.