Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 3/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL355499 | 0.90 | TNF (0.62) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL354801 | 0.87 | RXFP1 (0.55) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL354741 | 0.87 | TNF (0.53) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL355062 | 0.86 | PSEN1 (0.54) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL354539 | 0.84 | FABP4 (0.64) | SMN1; SMN2MAPTTP53KDM4ESLC6A4 | |
| SCHEMBL1004476 | 0.84 | TNF (0.63) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1004093 | 0.84 | TNF (0.63) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL352528 | 0.84 | MAPT (0.51) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12938925 | 0.83 | TNF (0.64) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL353749 | 0.81 | SMN1; SMN2 (0.49) | TNFPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015373-A1 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | GE HEALTHCARE UK LIMITED (GB) | 2012-01-19 | — | — | US | disclosed |
| US-8034558-B2 | Incubating dye of given formula with biological material, measuring fluorescence lifetime; lectins/glycoproteins, biotin/streptavidin, DNA/RNA | GE HEALTHCARE UK LIMITED (GB) | 2011-10-11 | — | — | US | disclosed |
| US-20110039289-A1 | FLUOROGENIC PEPTIDES AND THEIR METHOD OF PRODUCTION | ASSAYMETRICS LIMITED (GB) | 2011-02-17 | — | — | US | disclosed |
| EP-2268656-A1 | FLUOROGENIC PEPTIDES AND THEIR METHOD OF PRODUCTION | Assaymetrics Limited (GB) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009112791-A1 | FLUOROGENIC PEPTIDES AND THEIR METHOD OF PRODUCTION | ASSAYMETRICS LIMITED (GB) | 2009-09-17 | — | — | WO | disclosed |
| US-20080139788-A1 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | GE HEALTHCARE UK LIMITED (GB) | 2008-06-12 | — | — | US | disclosed |
| US-20040191792-A1 | Acridone derivatives as labels for fluorescence detection of target materials | GE HEALTHCARE UK LIMITED (GB) | 2004-09-30 | — | — | US | disclosed |
| EP-1392776-A2 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | Amersham Biosciences UK Limited (GB) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002099424-A2 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | AMERSHAM BIOSCIENCES UK LIMITED (GB) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039289-A1 | FLUOROGENIC PEPTIDES AND THEIR METHOD OF PRODUCTION | ACR, DNPEP, FIBP | TNF 1902/4885PSEN1 4485/4885PSEN2 4540/4885 |
| US-20080139788-A1 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS | ACR, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ARSA | TNF 4339/4885PSEN1 4493/4885PSEN2 4558/4885 |
| US-20040191792-A1 | Acridone derivatives as labels for fluorescence detection of target materials | ACR, ARSA, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | TNF 4012/4885PSEN1 4639/4885PSEN2 4753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.