Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ATP1A1 | P05023 | 6/20 | 0.38 |
| ▸ | ATP1B1 | P05026 | 6/20 | 0.38 |
| ▸ | ATP1A3 | P13637 | 6/20 | 0.38 |
| ▸ | ATP1B2 | P14415 | 6/20 | 0.38 |
| ▸ | ATP1A2 | P50993 | 6/20 | 0.38 |
| ▸ | ATP1B3 | P54709 | 6/20 | 0.38 |
| ▸ | FXYD2 | P54710 | 6/20 | 0.38 |
| ▸ | ATP1A4 | Q13733 | 6/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548953 | 0.86 | FLT3 (0.49) | IDH1LCKFLT3MAPK13MAPK12 | |
| SCHEMBL3551237 | 0.79 | TP53 (0.38) | IDH1TP53SMN1; SMN2ATP1A1ATP1B1 | |
| SCHEMBL3551921 | 0.78 | TP53 (0.43) | IDH1TP53SMN1; SMN2ATP1A1ATP1B1 | |
| SCHEMBL3552537 | 0.78 | TP53 (0.39) | IDH1TP53SMN1; SMN2ATP1A1ATP1B1 | |
| SCHEMBL3554499 | 0.78 | IGF1R (0.39) | IDH1TP53SMN1; SMN2ATP1A1ATP1B1 | |
| SCHEMBL3548594 | 0.78 | MAPK14 (0.40) | IDH1NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL3555836 | 0.77 | TP53 (0.38) | IDH1TP53SMN1; SMN2ATP1A1ATP1B1 | |
| SCHEMBL3549226 | 0.77 | HDAC6 (0.39) | IDH1TP53SMN1; SMN2ATP1A1ATP1B1 | |
| SCHEMBL3551389 | 0.77 | SMN1; SMN2 (0.38) | IDH1TP53SMN1; SMN2ATP1A1ATP1B1 | |
| SCHEMBL3550460 | 0.76 | IGF1R (0.43) | IDH1TP53SMN1; SMN2ATP1A1ATP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718801-B2 | Substituted imidazole derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-05-18 | — | — | US | disclosed |
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | MSD K.K. (JP) | 2008-03-20 | — | — | US | disclosed |
| EP-1790650-A1 | NOVEL SUBSTITUTED IMIDAZOLE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | PLK1, CDK1, CDK11A | IDH1 767/4885MEN1 885/4885NPC1 2808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.