Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.76 |
| ▸ | PRKCA | P17252 | 10/20 | 0.68 |
| ▸ | PRKCQ | Q04759 | 10/20 | 0.68 |
| ▸ | PRKCH | P24723 | 9/20 | 0.68 |
| ▸ | PRKCE | Q02156 | 9/20 | 0.68 |
| ▸ | PRKCD | Q05655 | 9/20 | 0.68 |
| ▸ | PRKCB | P05771 | 8/20 | 0.68 |
| ▸ | JAK1 | P23458 | 5/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | PRKCG | P05129 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16471240 | 0.90 | PRKCA (0.68) | JAK3PRKCAPRKCQPRKCHPRKCE | |
| SCHEMBL3553151 | 0.87 | JAK3 (0.59) | JAK3PRKCAPRKCQPRKCHPRKCE | |
| SCHEMBL29756398 | 0.86 | JAK3 (1.00) | JAK3 | |
| SCHEMBL21583823 | 0.86 | JAK3 (1.00) | JAK3 | |
| SCHEMBL21583824 | 0.84 | JAK3 (0.75) | JAK3PRKCAPRKCQPRKCHPRKCE | |
| SCHEMBL990657 | 0.84 | PRKCH (0.65) | JAK3PRKCAPRKCQPRKCHPRKCE | |
| SCHEMBL991233 | 0.84 | PRKCH (0.65) | JAK3PRKCAPRKCQPRKCHPRKCE | |
| SCHEMBL3546174 | 0.84 | PRKCA (0.73) | JAK3PRKCAPRKCQPRKCHPRKCE | |
| SCHEMBL3549510 | 0.84 | PRKCA (0.73) | JAK3PRKCAPRKCQPRKCHPRKCE | |
| SCHEMBL21583796 | 0.82 | JAK3 (0.81) | JAK3PRKCAPRKCQPRKCHPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747216-B1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | NOVARTIS AG (CH) | 2014-01-08 | — | — | EP | claimed |
| US-7851475-B2 | Substituted pyrrole-2, 5-diones as protein kinase C inhibitors | NOVARTIS AG (CH) | 2010-12-14 | — | — | US | claimed |
| US-20090221605-A1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | NOVARTIS AG (CH) | 2009-09-03 | — | — | US | claimed |
| EP-1747216-B1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | NOVARTIS AG (CH) | 2014-01-08 | — | — | EP | disclosed |
| US-7851475-B2 | Substituted pyrrole-2, 5-diones as protein kinase C inhibitors | NOVARTIS AG (CH) | 2010-12-14 | — | — | US | disclosed |
| US-7851475-B2 | Substituted pyrrole-2, 5-diones as protein kinase C inhibitors | NOVARTIS AG (CH) | 2010-12-14 | — | — | US | disclosed |
| US-7851475-B2 | Substituted pyrrole-2, 5-diones as protein kinase C inhibitors | NOVARTIS AG (CH) | 2010-12-14 | — | — | US | disclosed |
| US-20090221605-A1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | NOVARTIS AG (CH) | 2009-09-03 | — | — | US | disclosed |
| US-20090221605-A1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | NOVARTIS AG (CH) | 2009-09-03 | — | — | US | disclosed |
| US-20090221605-A1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | NOVARTIS AG (CH) | 2009-09-03 | — | — | US | disclosed |
| EP-1747216-A1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | Novartis Pharma AG. (CH) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005113545-A1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | NOVARTIS AG (CH) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221605-A1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | PRKCA, PRKCB, PRKCE | JAK3 135/4885PRKCA 1/4885PRKCQ 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.