Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.54 |
| ▸ | NT5E | P21589 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4481913 | 0.81 | HPGD (0.71) | KDM4EJAK2TYK2KCNK3KMT2A | |
| SCHEMBL27652929 | 0.81 | HPGD (0.76) | KCNK3KMT2AHPGDKCNK9NPC1 | |
| SCHEMBL1898755 | 0.81 | GAA (0.91) | GAAKDM4EL3MBTL1HTTMAPK1 | |
| SCHEMBL19242053 | 0.81 | GAA (1.00) | GAAKDM4EL3MBTL1HTTMAPK1 | |
| SCHEMBL19520192 | 0.80 | LMNA (0.69) | HTTKCNK3KMT2ALMNAALDH1A1 | |
| SCHEMBL27652922 | 0.79 | PTPN1 (0.61) | KDM4EKCNK3KMT2AHPGDPOLB | |
| SCHEMBL28472008 | 0.79 | HPGD (0.53) | KDM4EL3MBTL1KCNK3KMT2AHPGD | |
| SCHEMBL27652921 | 0.79 | KMT2A (0.57) | KDM4EL3MBTL1MAPK1KCNK3NT5E | |
| SCHEMBL23734986 | 0.78 | GAA (0.85) | GAAKDM4EL3MBTL1HTTMAPK1 | |
| Methyl Alcohol SCHEMBL28281305 | 0.77 | GAA (0.84) | GAAKDM4EL3MBTL1HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1946395-A | 1H-thieno [2, 3-c ] pyrazole derivatives useful as kinase inhibitors | PHARMACIA ITALIA SPA (IT) | 2007-04-11 | — | — | CN | claimed |
| US-7838676-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-11-23 | — | — | US | disclosed |
| CN-1946395-A | 1H-thieno [2, 3-c ] pyrazole derivatives useful as kinase inhibitors | PHARMACIA ITALIA SPA (IT) | 2007-04-11 | — | — | CN | disclosed |