Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7118049 | 0.80 | GSK3B (0.48) | GSK3BCA2CA1ALDH1A1CYP2A6 | |
| SCHEMBL12430908 | 0.80 | VCP (0.53) | CA2CA1ALDH1A1CYP2A6CA12 | |
| SCHEMBL8444868 | 0.78 | GSK3B (0.47) | GSK3BCA2CA1ALDH1A1CYP2A6 | |
| SCHEMBL31182393 | 0.78 | FFAR1 (0.50) | GSK3BCA2CA1ALDH1A1CYP2A6 | |
| SCHEMBL22905187 | 0.78 | APP (0.53) | CA2CA1ALDH1A1RAB9AKDM4E | |
| SCHEMBL28722702 | 0.78 | ACACB (0.46) | GSK3BCA2CA1ALDH1A1MAPT | |
| SCHEMBL31182389 | 0.78 | FFAR1 (0.50) | GSK3BCA2CA1ALDH1A1CYP2A6 | |
| SCHEMBL4487823 | 0.78 | ACACB (0.46) | GSK3BALDH1A1MAPTRAB9AKDM4E | |
| SCHEMBL9432042 | 0.78 | GABRP (0.48) | GSK3BCA2CA1ALDH1A1CYP2A6 | |
| 4-Phenyl-3-Butyn-2-One SCHEMBL433104 | 0.77 | NPSR1 (0.61) | ALDH1A1MAPTRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468727-A1 | Pyridine and pyrimidine derivatives as MGLUR2 antagonists | F. Hoffmann-La Roche AG (CH) | 2012-06-27 | — | — | EP | disclosed |
| US-8183262-B2 | Central nervous system disorders; metabotropic glutamate receptors (mGluR); 2-(4-Pyridin-3-yl-imidazol-1-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine | HOFFMANN-LA ROCHE INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-7642264-B2 | Phenyl-substituted pyrimidine derivatives as mGluR antagonists | HOFFMAN-LA ROCHE INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-20090318474-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS MGLUR 2 ANTAGONISTS | GATTI MCARTHUR SILVIA | 2009-12-24 | — | — | US | disclosed |
| EP-2001849-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2008-12-17 | — | — | EP | disclosed |
| US-7364841-B2 | Comprising support having thereon light-insensitive organic silver salt grains, photosensitive silver halide grains, a reducing agent for silver ions and a binder; improved storage stability, image lasting quality; use in medical diagnosis and graphic arts | KONICA MINOLTA & MEDICAL GRAPHIC, INC. (JP) | 2008-04-29 | — | — | US | disclosed |
| US-20070232583-A1 | Pyridine and pyrimidine derivatives as mGIuR2 antagonists | HOFFMANN-LA ROCHE INC. | 2007-10-04 | — | — | US | disclosed |
| WO-2007110337-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-04 | — | — | WO | disclosed |
| US-7202019-B2 | Photothermographic imaging material | KONICA MINOLTA HOLDINGS, INC. (JP) | 2007-04-10 | — | — | US | disclosed |
| US-7202019-B2 | Photothermographic imaging material | KONICA MINOLTA HOLDINGS, INC. (JP) | 2007-04-10 | — | — | US | disclosed |
| US-7175978-B2 | Silver salt photothermographic dry imaging material | KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) | 2007-02-13 | — | — | US | disclosed |
| US-7175978-B2 | Silver salt photothermographic dry imaging material | KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) | 2007-02-13 | — | — | US | disclosed |
| US-20070003886-A1 | SILVER SALT PHOTOTHERMOGRAPHIC DRY IMAGING MATERIAL | KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) | 2007-01-04 | — | — | US | disclosed |
| US-20070003886-A1 | SILVER SALT PHOTOTHERMOGRAPHIC DRY IMAGING MATERIAL | KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232583-A1 | Pyridine and pyrimidine derivatives as mGIuR2 antagonists | P2RX2, P2RY2, P2RX1 | GSK3B 1321/4885CA2 2101/4885CA1 4351/4885 |
| US-20090318474-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS MGLUR 2 ANTAGONISTS | GRM2, GRM1, GRM3 | GSK3B 1615/4885CA2 1337/4885CA1 3811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.