Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL119730 | 0.98 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2POLBKDM4EPLAU | |
| SCHEMBL30256557 | 0.82 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2POLBKDM4EPLAU | |
| SCHEMBL18094306 | 0.82 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2POLBKDM4EPLAU | |
| SCHEMBL24068078 | 0.82 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2POLBKDM4EPLAU | |
| SCHEMBL20350719 | 0.79 | TSHR (0.41) | ALDH1A1SMN1; SMN2POLBKDM4EPLAU | |
| Methane SCHEMBL28200241 | 0.79 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2POLBKDM4EPLAU | |
| SCHEMBL15181426 | 0.78 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2POLBKDM4EPLAU | |
| SCHEMBL30762204 | 0.77 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2POLBKDM4EPLAU | |
| SCHEMBL1716472 | 0.77 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2POLBKDM4EPLAU | |
| SCHEMBL29414916 | 0.77 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2POLBKDM4EPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795457-B2 | antitumor agents; anticancer agents; structurally related to the leptomycin family; Leptolstatin | KOSAN BIOSCIENCES INCORPORATED (US) | 2010-09-14 | — | — | US | disclosed |
| EP-2124927-A2 | CARBAMATE COMPOUNDS | Kosan Biosciences Incorporated (US) | 2009-12-02 | — | — | EP | disclosed |
| US-20080214617-A1 | Carbamate compounds | KOSAN BIOSCIENCES INCORPORATED | 2008-09-04 | — | — | US | disclosed |
| WO-2008106047-A2 | CARBAMATE COMPOUNDS | KOSAN BIOSCIENCES INCORPORATED (US) | 2008-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214617-A1 | Carbamate compounds | CPS1, RB1, PRMT1 | ALDH1A1 2117/4885SMN1; SMN2 4526/4885POLB 3095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.