Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 7/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 4/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.34 |
| ▸ | CLK1 | P49759 | 3/20 | 0.34 |
| ▸ | CLK2 | P49760 | 3/20 | 0.34 |
| ▸ | CLK3 | P49761 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561137 | 1.00 | CSF1R (0.40) | CSF1REGFRRAB9ANPC1POLB | |
| SCHEMBL3570497 | 0.87 | CDK4 (0.36) | CSF1RMAPT | |
| SCHEMBL3570500 | 0.87 | CDK4 (0.36) | CSF1RMAPT | |
| SCHEMBL3569499 | 0.81 | ALDH1A1 (0.44) | CSF1REGFRMAPTDYRK3DYRK1A | |
| SCHEMBL3569494 | 0.81 | ALDH1A1 (0.44) | CSF1REGFRMAPTDYRK3DYRK1A | |
| SCHEMBL3567249 | 0.81 | CSF1R (0.48) | CSF1RRAB9ANPC1POLBMAPT | |
| SCHEMBL3567242 | 0.81 | CSF1R (0.48) | CSF1RRAB9ANPC1POLBMAPT | |
| SCHEMBL3571309 | 0.81 | CSF1R (0.44) | CSF1RRAB9ANPC1POLBCSNK2A2 | |
| SCHEMBL3571312 | 0.81 | CSF1R (0.44) | CSF1RRAB9ANPC1POLBCSNK2A2 | |
| SCHEMBL13343924 | 0.80 | ALDH1A1 (0.43) | CSF1RMAPTHSD17B10DYRK3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713994-B2 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo,1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihyro-3 (2H)-isoquinolones and methods of use thereof | WYETH LLC (US) | 2010-05-11 | — | — | US | claimed |