Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.32 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.32 |
| ▸ | CDK1 | P06493 | 3/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3570497 | 1.00 | CDK4 (0.36) | CDK4CCND1CDK2KDM4EALDH1A1 | |
| SCHEMBL3561137 | 0.87 | CSF1R (0.40) | MAPTCSF1R | |
| SCHEMBL3561141 | 0.87 | CSF1R (0.40) | MAPTCSF1R | |
| SCHEMBL3560367 | 0.81 | ALDH1A1 (0.44) | CDK4CCND1CDK2KDM4EALDH1A1 | |
| SCHEMBL3560371 | 0.81 | ALDH1A1 (0.44) | CDK4CCND1CDK2KDM4EALDH1A1 | |
| SCHEMBL3562396 | 0.80 | PDGFRB (0.44) | CDK4CCND1CDK2ALDH1A1MAPT | |
| SCHEMBL3562399 | 0.80 | PDGFRB (0.44) | CDK4CCND1CDK2ALDH1A1MAPT | |
| SCHEMBL3570607 | 0.79 | CDK4 (0.39) | CDK4CCND1CDK2LMNAMAPT | |
| SCHEMBL13344041 | 0.79 | CDK4 (0.39) | CDK4CCND1CDK2LMNAMAPT | |
| SCHEMBL3570604 | 0.79 | CDK4 (0.39) | CDK4CCND1CDK2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713994-B2 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo,1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihyro-3 (2H)-isoquinolones and methods of use thereof | WYETH LLC (US) | 2010-05-11 | — | — | US | claimed |