(S)-Methylphenobarbital

(S)-Methylphenobarbital

SCHEMBL35625

CC[C@]1(c2ccccc2)C(=O)NC(=O)N(C)C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 1.00
CYP2C19 P33261 4/20 0.64
KMT2A Q03164 2/20 0.61
TSHR P16473 2/20 0.55
MEN1 O00255 1/20 0.54
CYP1A2 P05177 1/20 0.54
POLB P06746 1/20 0.54
APEX1 P27695 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
MMP2 P08253 3/20 0.51
MMP9 P14780 3/20 0.51
MMP3 P08254 2/20 0.51
GABRA1 P14867 3/20 0.43
GABRG2 P18507 3/20 0.43
GABRB3 P28472 3/20 0.43
GABRB2 P47870 2/20 0.43
ELANE P08246 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mephobarbital SCHEMBL35624 1.00 LMNA (1.00) LMNACYP2C19KMT2ATSHRMEN1
(R)-Methylphenobarbital SCHEMBL11789851 1.00 LMNA (1.00) LMNACYP2C19KMT2ATSHRMEN1
Mephobarbital SCHEMBL28475568 0.98 LMNA (0.97) LMNACYP2C19KMT2ATSHRMEN1
Mephobarbital SCHEMBL29694125 0.98 LMNA (0.97) LMNACYP2C19KMT2ATSHRMEN1
Mephobarbital SCHEMBL7777123 0.94 LMNA (0.88) LMNACYP2C19KMT2ATSHRMEN1
Mephobarbital SCHEMBL1004749 0.93 LMNA (0.86) LMNACYP2C19KMT2ATSHRMEN1
Mephobarbital SCHEMBL17416929 0.91 LMNA (0.83) LMNACYP2C19KMT2ATSHRMEN1
SCHEMBL29402420 0.87 LMNA (0.77) LMNACYP2C19KMT2ATSHRMEN1
SCHEMBL5494690 0.85 LMNA (0.73) LMNACYP2C19KMT2ATSHRMEN1
SCHEMBL29819552 0.84 LMNA (0.73) LMNACYP2C19KMT2ATSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 10643 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
EP-4622640-A1 COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF Brightseed, Inc. (US) 2025-10-01 EP claimed
US-20250281451-A1 COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF BRIGHTSEED, INC. 2025-09-11 US claimed
EP-3441087-B1 METHODS OF TREATING CHRONIC PAIN TEVA PHARMACEUTICALS INT GMBH (CH) 2025-02-19 EP claimed
US-12133922-B2 Abuse resistant capsule R.P. SCHERER TECHNOLOGIES, LLC (US) 2024-11-05 US claimed
WO-2024150170-A1 PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA NEURIM PHARMACEUTICALS (1991) LTD. (IL) 2024-07-18 WO claimed
US-20240238250-A1 METHOD OF USING PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA NEURIM PHARMACEUTICALS (1991) LTD. (IL) 2024-07-18 US claimed
WO-2024112947-A1 COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF BRIGHTSEED, INC. (US) 2024-05-30 WO claimed
WO-2023055939-A9 APPARATUS, SYSTEMS AND METHODS FOR TRANSDERMAL DRUG DELIVERY, PERMEABILITY ENHANCEMENT AND AUGMENTATION UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2024-04-25 WO claimed
US-11858909-B2 Deuterated etoricoxib, methods of manufacture, and use thereof Tremeau Pharmaceuticals, Inc. (US) 2024-01-02 US claimed
EP-0566289-A1 Analysis of hemoglobin variants by capillary electrophoresis BECKMAN INSTRUMENTS, INC. (US) 1993-10-20 EP claimed
US-5202006-A Using barbituric acid buffer BECKMAN INSTRUMENTS, INC. (US) 1993-04-13 US claimed
US-5192550-A Dosage form for treating central nervous system disorders ALZA CORPORATION (US) 1993-03-09 US claimed
EP-0308473-A1 INFRARED IMMUNOLOGICAL DOSING CNRS, Centre National de la Recherche Scientifique (FR) 1989-03-29 EP claimed
WO-1988007684-A2 INFRARED IMMUNOLOGICAL DOSING CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS (FR) 1988-10-06 WO claimed
US-4557934-A ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE THE PROCTER & GAMBLE COMPANY (US) 1985-12-10 US claimed
US-4458044-A PREVENTION OF FORMATION OF WATER TREES SIEMENS AKTIENGESELLSCHAFT (DE) 1984-07-03 US claimed
US-4175119-A Composition and method to prevent accidental and intentional overdosage with psychoactive drugs PORTER GARRY L 1979-11-20 US claimed
US-4126684-A 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE CIBA-GEIGY CORPORATION (US) 1978-11-21 US claimed
US-3995021-A DIAZOTIZATION OF AN AMINO PHENYL SUBSTITUTED HAPTEN BIOLOGICAL DEVELOPMENTS, INC. (US) 1976-11-30 US claimed