Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.36 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27469941 | 0.80 | HTR1A (0.38) | SLC6A2SLC6A4SLC6A3TRPM5HTR1A | |
| SCHEMBL30743773 | 0.78 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3TRPM5ACHE | |
| SCHEMBL15896884 | 0.78 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3TRPM5ACHE | |
| SCHEMBL13616555 | 0.78 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3TRPM5ACHE | |
| SCHEMBL18300391 | 0.77 | KDM1A (0.39) | SLC6A2SLC6A4SRD5A1HTR2AHTR2C | |
| SCHEMBL5097822 | 0.77 | MAP3K14 (0.42) | SLC6A2SLC6A4TRPM5HTR1ACHRNB2 | |
| SCHEMBL17193850 | 0.77 | TRPM5 (0.41) | SLC6A2SLC6A4SLC6A3TRPM5ACHE | |
| SCHEMBL15933219 | 0.77 | HTR2C (0.45) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL18427870 | 0.77 | TRPM5 (0.41) | SLC6A2SLC6A4SLC6A3TRPM5ACHE | |
| SCHEMBL15702940 | 0.77 | HTR2C (0.45) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049112-B1 | TREATING INFECTIONS AND SEQUELAE THEREOF WITH COMBINED DISSOCIATED GLUCOCORTICOID RECEPTOR AGONISTS AND ANTI-INFECTIVE AGENTS | BAUSCH & LOMB (US) | 2012-03-14 | — | — | EP | disclosed |