Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 7/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318378 | 0.96 | TDO2 (0.44) | FEN1ALOX5APTDO2DHFR | |
| SCHEMBL3450475 | 0.94 | TDO2 (0.46) | FEN1ALOX5APTDO2DHFR | |
| SCHEMBL1320584 | 0.94 | TDO2 (0.46) | FEN1ALOX5APTDO2DHFR | |
| SCHEMBL2444528 | 0.92 | DHFR (0.41) | FEN1ALOX5APTDO2DHFR | |
| SCHEMBL30714999 | 0.92 | DHFR (0.41) | FEN1ALOX5APTDO2DHFR | |
| SCHEMBL1512134 | 0.83 | DHFR (0.46) | DHFR | |
| SCHEMBL3779654 | 0.83 | HRH4 (0.45) | DHFR | |
| SCHEMBL5781142 | 0.83 | DHFR (0.37) | FEN1ALOX5APDHFR | |
| SCHEMBL12541973 | 0.83 | DHFR (0.37) | DHFR | |
| SCHEMBL12541975 | 0.83 | DHFR (0.37) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113061116-A | Aminopyrimidine compound, preparation method, composition and application thereof | 上海医药工业研究院 | 2021-07-02 | — | — | CN | disclosed |
| CN-110467638-A | A kind of double amino Chloropyrimide class compounds containing m-chloroaniline class substituent group, preparation method and applications | BEIJING SAITE MINGQIANG MEDICINE TECH CO LTD | 2019-11-19 | — | — | CN | disclosed |
| US-7820648-B2 | Pyrimidine derivatives for the treatment of abnormal cell growth | PFIZER INC (US) | 2010-10-26 | — | — | US | disclosed |
| US-20080234303-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER INC | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234303-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | CCNB1, TYMS, CCNA1 | FEN1 2694/4885ALOX5AP 3643/4885TDO2 1889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.