Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.43 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | RUVBL1 | Q9Y265 | 4/20 | 0.41 |
| ▸ | GOT1 | P17174 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3570026 | 0.86 | MAPT (0.39) | F10 | |
| SCHEMBL3566368 | 0.85 | F10 (0.42) | F10 | |
| SCHEMBL3566097 | 0.83 | CCKBR (0.57) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3574164 | 0.82 | F10 (0.40) | F10 | |
| SCHEMBL3563906 | 0.81 | F10 (0.40) | F10 | |
| SCHEMBL3562609 | 0.81 | F10 (0.40) | F10 | |
| SCHEMBL3564282 | 0.80 | F10 (0.39) | F10 | |
| SCHEMBL3569443 | 0.79 | F10 (0.39) | F10 | |
| SCHEMBL3574011 | 0.79 | F10 (0.39) | F10 | |
| SCHEMBL3563374 | 0.79 | F10 (0.39) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678913-B2 | Ureas as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-03-16 | — | — | US | claimed |
| US-20060160821-A1 | Ureas as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2006-07-20 | — | — | US | claimed |
| US-7678913-B2 | Ureas as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-20060160821-A1 | Ureas as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2006-07-20 | — | — | US | disclosed |
| WO-2006063113-A2 | UREAS AS FACTOR XA INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160821-A1 | Ureas as factor Xa inhibitors | TFPI, F12, F11 | HDAC8 1082/4885HDAC3 632/4885HDAC4 1366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.