Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 3/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3080110 | 0.93 | PRKCA (0.45) | PRKCAMMP12SCN9AKDM4ESMN1; SMN2 | |
| SCHEMBL4920282 | 0.88 | PRKCA (0.43) | PRKCAMMP12SCN9AESR1ESR2 | |
| SCHEMBL3569335 | 0.86 | PRKCA (0.40) | PRKCAMMP12SCN9AESR1ESR2 | |
| SCHEMBL4916577 | 0.85 | PRKCA (0.53) | PRKCAMMP12SCN9ALMNANR1I2 | |
| SCHEMBL2156364 | 0.83 | KDM4E (0.36) | PRKCAMMP12KDM4ESMN1; SMN2ESR1 | |
| Trifluoroacetic Acid SCHEMBL3097978 | 0.83 | PRKCA (0.60) | PRKCAMMP12SCN9AKDM4ESMN1; SMN2 | |
| SCHEMBL3569883 | 0.82 | PRKCA (0.47) | PRKCAMMP12SCN9AKDM4ESMN1; SMN2 | |
| SCHEMBL3092706 | 0.81 | PRKCA (0.46) | PRKCAMMP12SCN9AKDM4ESMN1; SMN2 | |
| SCHEMBL4830061 | 0.81 | PRKCA (0.55) | PRKCAMMP12SCN9AALDH1A1POLB | |
| SCHEMBL4827957 | 0.80 | PRKCA (0.55) | PRKCAMMP12SCN9APOLBNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080261938-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2008-10-23 | — | — | US | claimed |
| US-7662809-B2 | Tetracyclic indole derivatives as antiviral agents | ISTITUTO DI RICHERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2010-02-16 | — | — | US | disclosed |
| US-20080261938-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261938-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | IDO1, IDO2, HAVCR2 | PRKCA 4232/4885MMP12 2495/4885SCN9A 3739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.