Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | ESR1 | P03372 | 11/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PLD2 | O14939 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | C5 | P01031 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3567161 | 0.86 | PRKCA (0.49) | PRKCAMMP12SCN9AESR1ESR2 | |
| SCHEMBL3575065 | 0.83 | SCN9A (0.39) | PRKCAMMP12SCN9AESR1ESR2 | |
| SCHEMBL4920282 | 0.83 | PRKCA (0.43) | PRKCAMMP12SCN9AESR1ESR2 | |
| SCHEMBL3080110 | 0.80 | PRKCA (0.45) | PRKCAMMP12SCN9AESR1ESR2 | |
| Trifluoroacetic Acid SCHEMBL3097978 | 0.75 | PRKCA (0.60) | PRKCAMMP12SCN9AESR1ESR2 | |
| SCHEMBL3093288 | 0.75 | PRKCA (0.48) | PRKCAMMP12SCN9ACSNK2A1NR1I2 | |
| Trifluoroacetic Acid SCHEMBL3098231 | 0.74 | PRKCA (0.50) | PRKCAMMP12SCN9AESR1ESR2 | |
| SCHEMBL3569883 | 0.74 | PRKCA (0.47) | PRKCAMMP12SCN9AESR1ESR2 | |
| SCHEMBL3581080 | 0.73 | SCN9A (0.38) | PRKCAMMP12SCN9ANR1I2ALDH1A1 | |
| SCHEMBL3092706 | 0.73 | PRKCA (0.46) | PRKCAMMP12SCN9AESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662809-B2 | Tetracyclic indole derivatives as antiviral agents | ISTITUTO DI RICHERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2010-02-16 | — | — | US | disclosed |
| US-20080261938-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261938-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | IDO1, IDO2, HAVCR2 | PRKCA 4232/4885MMP12 2495/4885SCN9A 3739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.