Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | PLK1 | P53350 | 5/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3567289 | 1.00 | PKM (0.39) | PKMMAPTAKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL3146777 | 0.92 | PKM (0.41) | PKMMAPTAKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL3577255 | 0.87 | PLK1 (0.38) | MAPTAKR1C3AKR1C2ALDH1A1SMN1; SMN2 | |
| SCHEMBL3577258 | 0.87 | PLK1 (0.38) | MAPTAKR1C3AKR1C2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4354043 | 0.86 | AKR1C3 (0.41) | PKMMAPTAKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL4354039 | 0.86 | AKR1C3 (0.41) | PKMMAPTAKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL3577059 | 0.86 | PLK1 (0.40) | PLK1PLK3CDK2IKBKE | |
| SCHEMBL4632609 | 0.81 | PLK1 (0.35) | MAPTAKR1C3AKR1C2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4632611 | 0.81 | PLK1 (0.35) | MAPTAKR1C3AKR1C2ALDH1A1SMN1; SMN2 | |
| SCHEMBL5008912 | 0.81 | ALDH1A1 (0.38) | MAPTAKR1C3AKR1C2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056525-A1 | 5- AND 6- SUBSTITUTED BENZIMIDAZOLE THIOPHENE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2010-03-04 | — | — | US | disclosed |
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | SMITHKLINE BEECHAM CORPORATION | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056525-A1 | 5- AND 6- SUBSTITUTED BENZIMIDAZOLE THIOPHENE COMPOUNDS | CYP3A5, CYP2B6, CYP3A4 | PKM 609/4885MAPT 1359/4885AKR1C3 2648/4885 |
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | CYP3A4, CYP2C19, CYP2B6 | PKM 524/4885MAPT 2606/4885AKR1C3 591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.