Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.33 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3574896 | 0.99 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP3A4MDM2IDO1 | |
| SCHEMBL3575980 | 0.89 | CYP11B2 (0.60) | CYP11B1CYP11B2MDM2CYP19A1KCNH2 | |
| SCHEMBL3573743 | 0.88 | CYP11B1 (0.52) | CYP11B1CYP11B2CYP3A4IDO1COMT | |
| Hydrochloric Acid SCHEMBL3567622 | 0.88 | CYP11B2 (0.59) | CYP11B1CYP11B2MDM2CYP19A1KCNH2 | |
| Hydrochloric Acid SCHEMBL3573955 | 0.88 | CYP11B1 (0.51) | CYP11B1CYP11B2CYP3A4IDO1COMT | |
| SCHEMBL3575270 | 0.87 | CYP11B1 (0.61) | CYP11B1CYP11B2CYP3A4MDM2CYP19A1 | |
| SCHEMBL3578755 | 0.87 | CYP11B1 (0.77) | CYP11B1CYP11B2CYP3A4CYP19A1KCNH2 | |
| Hydrochloric Acid SCHEMBL3571529 | 0.86 | CYP11B1 (0.60) | CYP11B1CYP11B2CYP3A4MDM2CYP19A1 | |
| Hydrochloric Acid SCHEMBL3574873 | 0.86 | CYP11B1 (0.75) | CYP11B1CYP11B2CYP3A4CYP19A1KCNH2 | |
| SCHEMBL3569027 | 0.86 | CYP11B1 (0.75) | CYP11B1CYP11B2CYP3A4MDM2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732603-B2 | Organic compounds as agents for the treatment of aldosterone mediated conditions | NOVARTIS AG (CH) | 2010-06-08 | — | — | US | claimed |
| EP-1537114-B1 | ORGANIC COMPOUNDS AS AGENTS FOR THE TREATMENT OF ALDOSTERONE MEDIATED CONDITIONS | NOVARTIS AG (CH) | 2006-08-09 | — | — | EP | claimed |
| US-20060166973-A1 | Organic compounds as agents for the treatment of aldosterone mediated conditions | NOVARTIS AG (CH) | 2006-07-27 | — | — | US | claimed |
| US-7732603-B2 | Organic compounds as agents for the treatment of aldosterone mediated conditions | NOVARTIS AG (CH) | 2010-06-08 | — | — | US | disclosed |
| US-7732603-B2 | Organic compounds as agents for the treatment of aldosterone mediated conditions | NOVARTIS AG (CH) | 2010-06-08 | — | — | US | disclosed |
| US-7732603-B2 | Organic compounds as agents for the treatment of aldosterone mediated conditions | NOVARTIS AG (CH) | 2010-06-08 | — | — | US | disclosed |
| EP-1537114-B1 | ORGANIC COMPOUNDS AS AGENTS FOR THE TREATMENT OF ALDOSTERONE MEDIATED CONDITIONS | NOVARTIS AG (CH) | 2006-08-09 | — | — | EP | disclosed |
| US-20060166973-A1 | Organic compounds as agents for the treatment of aldosterone mediated conditions | NOVARTIS AG (CH) | 2006-07-27 | — | — | US | disclosed |
| WO-2004014914-A1 | ORGANIC COMPOUNDS AS AGENTS FOR THE TREATMENT OF ALDOSTERONE MEDIATED CONDITIONS | NOVARTIS AG (CH) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166973-A1 | Organic compounds as agents for the treatment of aldosterone mediated conditions | CYP11B1, CYP27A1, CYP17A1 | CYP11B1 1/4885CYP11B2 6/4885CYP3A4 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.