Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPN | P05981 | 4/20 | 0.44 |
| ▸ | PLAU | P00749 | 3/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3574348 | 1.00 | TSHR (0.47) | TSHRHTTHSD17B10POLBADORA3 | |
| SCHEMBL19858148 | 0.87 | HPN (0.46) | POLBALDH1A1ENPP3ENPP1ENPP2 | |
| SCHEMBL3254319 | 0.79 | ALDH1A1 (0.50) | POLBALDH1A1GAALMNA | |
| SCHEMBL3725641 | 0.79 | ALDH1A1 (0.50) | POLBALDH1A1GAALMNA | |
| SCHEMBL723060 | 0.79 | ALDH1A1 (0.50) | POLBALDH1A1GAALMNA | |
| SCHEMBL6586026 | 0.77 | ALDH1A1 (0.51) | TSHRHTTHSD17B10POLBADORA3 | |
| SCHEMBL20968996 | 0.77 | ALDH1A1 (0.47) | POLBALDH1A1HPNPLAUGAA | |
| SCHEMBL2754706 | 0.77 | ALDH1A1 (0.51) | TSHRHTTHSD17B10POLBADORA3 | |
| SCHEMBL5159692 | 0.77 | ALDH1A1 (0.47) | POLBALDH1A1HPNPLAUGAA | |
| Cyclohexylglycyl SCHEMBL3574344 | 0.77 | ADORA3 (0.46) | TSHRHTTHSD17B10POLBADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004250-A1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD. (GB) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004250-A1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | PLK2, PLK4, PLK3 | TSHR 590/4885HTT 4514/4885HSD17B10 1856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.