Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 3/20 | 0.48 |
| ▸ | CAMKK2 | Q96RR4 | 9/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3568847 | 0.91 | MAP4K1 (0.60) | MAP4K1CYP3A4ABL1CAMKK2 | |
| SCHEMBL13342406 | 0.82 | MAP4K1 (0.40) | MAP4K1CYP3A4ABL1NTRK1AAK1 | |
| SCHEMBL13342403 | 0.74 | MAP4K1 (0.44) | MAP4K1CYP3A4ABL1NTRK1JAK3 | |
| SCHEMBL3562909 | 0.73 | MAP4K1 (0.82) | MAP4K1CYP3A4ABL1CAMKK2NTRK1 | |
| SCHEMBL3567049 | 0.68 | MAP4K1 (0.41) | MAP4K1CYP3A4ABL1 | |
| SCHEMBL13342408 | 0.68 | HSD17B10 (0.37) | CYP3A4MAPK1GSK3BDYRK1ACLK4 | |
| SCHEMBL3723996 | 0.66 | ROCK2 (0.45) | MAP4K1CYP3A4ABL1ROCK2ROCK1 | |
| SCHEMBL31318238 | 0.66 | MAP4K1 (0.70) | MAP4K1CYP3A4ABL1CAMKK2AURKA | |
| SCHEMBL3489349 | 0.66 | MAP4K1 (0.59) | MAP4K1CYP3A4ABL1CAMKK2CDC7 | |
| SCHEMBL13342614 | 0.65 | MAP4K1 (0.77) | MAP4K1CYP3A4ABL1CAMKK2SGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709645-B2 | Pyrrolo-pyridine kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2010-05-04 | — | — | US | disclosed |
| US-20090143352-A1 | PYRROLO-PYRIDINE KINASE MODULATIORS | SGX PHARMACEUTICALS, INC. (US) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143352-A1 | PYRROLO-PYRIDINE KINASE MODULATIORS | MAP4K2, PDXK, MAP4K1 | MAP4K1 3/4885CYP3A4 3552/4885ABL1 348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.