Sugi Predict

Sugi Predict / Compounds / SCHEMBL3569632

SCHEMBL3569632

SCHEMBL3569632

O=C(O)Cc1cc(OCc2ccccc2)cc(-c2ccccc2)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PPARG P37231 2/20 0.62
▸ PPARD Q03181 2/20 0.62
▸ LTB4R Q15722 2/20 0.57
▸ LTB4R2 Q9NPC1 2/20 0.57
▸ MEN1 O00255 1/20 0.54
▸ KMT2A Q03164 1/20 0.54
▸ FFAR1 O14842 5/20 0.53
▸ FFAR4 Q5NUL3 2/20 0.53
▸ AKR1B1 P15121 1/20 0.53
▸ NR4A2 P43354 1/20 0.52
▸ MRGPRX4 Q96LA9 1/20 0.52
▸ PTPN1 P18031 1/20 0.52
▸ CFD P00746 1/20 0.52
▸ GSTP1 P09211 2/20 0.50
▸ ABCC4 O15439 1/20 0.50
▸ LMNA P02545 1/20 0.50
▸ GAA P10253 1/20 0.50
▸ TSHR P16473 1/20 0.50
▸ PTGS1 P23219 1/20 0.50
▸ HTT P42858 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3578107 0.93 PPARG (0.55) PPARGPPARDLTB4RLTB4R2MEN1
SCHEMBL3576743 0.90 MRGPRX4 (0.54) PPARGPPARDLTB4RLTB4R2MEN1
SCHEMBL3572558 0.90 PPARD (0.53) PPARGPPARDLTB4RLTB4R2MEN1
SCHEMBL3576903 0.90 CFD (0.53) PPARGPPARDLTB4RLTB4R2MEN1
SCHEMBL3575842 0.90 FFAR1 (0.55) PPARGPPARDLTB4RLTB4R2MEN1
SCHEMBL3569849 0.89 PPARD (0.56) PPARGPPARDLTB4RLTB4R2FFAR1
SCHEMBL2957881 0.89 MEN1 (0.67) LTB4RLTB4R2MEN1KMT2AFFAR1
SCHEMBL9205498 0.89 LTB4R (0.68) LTB4RLTB4R2MEN1KMT2AFFAR1
SCHEMBL3565011 0.89 LTB4R (0.53) PPARGPPARDLTB4RLTB4R2MEN1
SCHEMBL3567119 0.89 LTB4R (0.53) PPARGPPARDLTB4RLTB4R2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101084178-B (biphenyl) carboxylic acids and derivatives thereof CELLZOME AG 2012-03-28 — — CN claimed
US-7825160-B2 such as [5-(4-Fluoro-benzyloxy)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid, used for the treatment of Alzheimer's disease and for the modulation of gamma -secretase activity CELLZOME LIMITED (GB) 2010-11-02 — — US claimed
US-20090118289-A1 (Biphenyl) Carboxylic Acids and Derivatives Thereof CELLZOME AG (DE) 2009-05-07 — — US claimed
EP-1805129-B1 (BIPHENYL) CARBOXYLIC ACIDS AND DERIVATIVES THEREOF CELLZOME LTD (GB) 2009-03-18 — — EP claimed
CN-101084178-A (Biphenyl) carboxylic acids and derivatives thereof CELLZOME AG (DE) 2007-12-05 — — CN claimed
EP-1805129-A1 (BIPHENYL) CARBOXYLIC ACIDS AND DERIVATIVES THEREOF CELLZOME AG (DE) 2007-07-11 — — EP claimed
WO-2006045554-A1 (BIPHENYL) CARBOXYLIC ACIDS AND DERIVATIVES THEREOF CELLZOME AG (DE) 2006-05-04 — — WO claimed
US-8692017-B2 Carbon linked modulators of gamma-secretase JANSSEN PHARMACEUTICA, N.V. (BE) 2014-04-08 — — US disclosed
US-8252935-B2 Piperidinyl and piperazinyl modulators of γ-secretase JANSSEN PHARMACEUTICA N.V. (BE) 2012-08-28 — — US disclosed
US-8247610-B2 Amine linked modulators of γ-secretase JANSSEN PHARMACEUTICA N.V. (BE) 2012-08-21 — — US disclosed
CN-101084178-B (biphenyl) carboxylic acids and derivatives thereof CELLZOME AG 2012-03-28 — — CN disclosed
US-8106236-B2 Triaryl compounds and derivates thereof ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2012-01-31 — — US disclosed
US-7951843-B2 Amide linked modulators of γ-secretase JANSSEN PHARMACEUTICA N.V. (BE) 2011-05-31 — — US disclosed
US-20090105344-A1 BIPHENYL CARBOXYLIC ACIDS AND DERIVATIVES THEREOF JANSSEN PHARMACEUTICA N.V. (BE) 2009-04-23 — — US disclosed
EP-1805129-B1 (BIPHENYL) CARBOXYLIC ACIDS AND DERIVATIVES THEREOF CELLZOME LTD (GB) 2009-03-18 — — EP disclosed
US-20070293567-A1 SUBSTITUTED BIPHENYL CARBOXYLIC ACIDS AND DERIVATIVES THEREOF ORTHO-MCNEIL PHARMACEUTICAL, INC. 2007-12-20 — — US disclosed
CN-101084178-A (Biphenyl) carboxylic acids and derivatives thereof CELLZOME AG (DE) 2007-12-05 — — CN disclosed
US-20070254957-A1 TRIARYL COMPOUNDS AND DERIVATES THEREOF ORTHO-MCNEIL PHARMACEUTICAL, INC. 2007-11-01 — — US disclosed
EP-1805129-A1 (BIPHENYL) CARBOXYLIC ACIDS AND DERIVATIVES THEREOF CELLZOME AG (DE) 2007-07-11 — — EP disclosed
WO-2006045554-A1 (BIPHENYL) CARBOXYLIC ACIDS AND DERIVATIVES THEREOF CELLZOME AG (DE) 2006-05-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070293567-A1 SUBSTITUTED BIPHENYL CARBOXYLIC ACIDS AND DERIVATIVES THEREOF BACE1, BACE2, APP PPARG 62/4885PPARD 135/4885LTB4R 2233/4885
US-20090105344-A1 BIPHENYL CARBOXYLIC ACIDS AND DERIVATIVES THEREOF BACE1, BACE2, APP PPARG 42/4885PPARD 125/4885LTB4R 1635/4885
US-20090118289-A1 (Biphenyl) Carboxylic Acids and Derivatives Thereof BACE1, BACE2, APP PPARG 239/4885PPARD 455/4885LTB4R 1634/4885
US-20070254957-A1 TRIARYL COMPOUNDS AND DERIVATES THEREOF BACE1, BACE2, APP PPARG 463/4885PPARD 488/4885LTB4R 2090/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.