Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | PPARA | Q07869 | 3/20 | 0.39 |
| ▸ | CCR9 | P51686 | 3/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | YAP1 | P46937 | 1/20 | 0.35 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.35 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PDE6D | O43924 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576208 | 0.90 | NLRP3 (0.42) | NLRP3LMNAPPARGPPARACCR9 | |
| SCHEMBL3580041 | 0.89 | LPAR1 (0.41) | NLRP3PPARGPPARACCR9PPARD | |
| SCHEMBL3569645 | 0.86 | CCR9 (0.43) | NLRP3PPARGPPARACCR9PPARD | |
| SCHEMBL3581908 | 0.86 | NLRP3 (0.41) | NLRP3PPARGPPARACCR9PPARD | |
| SCHEMBL3579102 | 0.85 | LPAR1 (0.41) | NLRP3PPARGPPARACCR9LPAR1 | |
| SCHEMBL3576346 | 0.85 | CNR1 (0.38) | POLBPPARGPPARAPPARDLPAR1 | |
| SCHEMBL3572707 | 0.82 | CCR9 (0.42) | CCR9LPAR1LPAR2LPAR5CYP3A4 | |
| SCHEMBL3576449 | 0.81 | LPAR1 (0.39) | NLRP3CCR9LPAR1LPAR2LPAR5 | |
| SCHEMBL3577563 | 0.80 | NLRP3 (0.42) | NLRP3PPARGPPARAPPARDLPAR1 | |
| SCHEMBL3577122 | 0.79 | NLRP3 (0.42) | NLRP3LPAR1LPAR2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |