Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | CCR9 | P51686 | 4/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579102 | 0.95 | LPAR1 (0.41) | NLRP3PPARGPPARACCR9LPAR1 | |
| SCHEMBL3569645 | 0.91 | CCR9 (0.43) | NLRP3PPARGPPARACCR9LPAR1 | |
| SCHEMBL3581908 | 0.91 | NLRP3 (0.41) | NLRP3PPARGPPARACCR9LPAR1 | |
| SCHEMBL3580041 | 0.90 | LPAR1 (0.41) | NLRP3PPARGPPARACCR9LPAR1 | |
| SCHEMBL3569879 | 0.90 | POLB (0.46) | NLRP3PPARGPPARACCR9LPAR1 | |
| SCHEMBL3577122 | 0.89 | NLRP3 (0.42) | NLRP3LPAR1LPAR2SLC2A1C5AR1 | |
| SCHEMBL3581190 | 0.87 | TRPV1 (0.41) | CCR9LPAR1LPAR5LPAR2CYP3A4 | |
| SCHEMBL3574141 | 0.87 | LPAR1 (0.41) | NLRP3PPARGPPARALPAR1LPAR5 | |
| SCHEMBL3581435 | 0.86 | TP53 (0.41) | NLRP3CCR9LPAR1LPAR5C5AR1 | |
| SCHEMBL3572707 | 0.86 | CCR9 (0.42) | CCR9LPAR1LPAR5LPAR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |