Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4607134 | 0.94 | MEN1 (0.52) | MEN1KMT2AGAAPOLBTGFBR1 | |
| SCHEMBL4603646 | 0.94 | MEN1 (0.51) | MEN1KMT2AGAAPOLBTGFBR1 | |
| SCHEMBL3353592 | 0.93 | L3MBTL1 (0.55) | MEN1KMT2AGAAPOLBTGFBR1 | |
| SCHEMBL13166141 | 0.93 | L3MBTL1 (0.55) | MEN1KMT2AGAAPOLBTGFBR1 | |
| SCHEMBL4605916 | 0.92 | MEN1 (0.53) | MEN1KMT2AGAAPOLBTGFBR1 | |
| SCHEMBL3350708 | 0.91 | MEN1 (0.49) | MEN1KMT2AGAAPOLBTGFBR1 | |
| SCHEMBL3350714 | 0.91 | MEN1 (0.49) | MEN1KMT2AGAAPOLBTGFBR1 | |
| SCHEMBL13336340 | 0.91 | MEN1 (0.49) | MEN1KMT2AGAAPOLBTGFBR1 | |
| SCHEMBL3353174 | 0.91 | MEN1 (0.49) | MEN1KMT2AGAAPOLBTGFBR1 | |
| SCHEMBL4603914 | 0.91 | TGFBR1 (0.58) | MEN1KMT2AGAAPOLBTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753512-B1 | TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2008-07-09 | — | — | EP | claimed |
| US-7803945-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-09-28 | — | — | US | disclosed |