Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 4/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.37 |
| ▸ | CLK1 | P49759 | 3/20 | 0.37 |
| ▸ | CLK2 | P49760 | 3/20 | 0.37 |
| ▸ | CLK3 | P49761 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3573495 | 1.00 | CSF1R (0.41) | CSF1RTNK2DYRK3DYRK1ADYRK2 | |
| SCHEMBL13343924 | 0.89 | ALDH1A1 (0.43) | CSF1RTNK2DYRK3DYRK1ADYRK2 | |
| SCHEMBL3568650 | 0.86 | CSF1R (0.41) | CSF1RTNK2DYRK3DYRK1ADYRK2 | |
| SCHEMBL3568645 | 0.86 | CSF1R (0.41) | CSF1RTNK2DYRK3DYRK1ADYRK2 | |
| SCHEMBL3656634 | 0.85 | CSF1R (0.42) | CSF1RTNK2DYRK3DYRK1ADYRK2 | |
| SCHEMBL3562396 | 0.85 | PDGFRB (0.44) | CSF1RTNK2DYRK3DYRK1ADYRK2 | |
| SCHEMBL3569494 | 0.85 | ALDH1A1 (0.44) | CSF1RTNK2DYRK3DYRK1ADYRK2 | |
| SCHEMBL3656639 | 0.85 | CSF1R (0.42) | CSF1RTNK2DYRK3DYRK1ADYRK2 | |
| SCHEMBL3569499 | 0.85 | ALDH1A1 (0.44) | CSF1RTNK2DYRK3DYRK1ADYRK2 | |
| SCHEMBL3570748 | 0.85 | CSF1R (0.42) | CSF1RTNK2DYRK3DYRK1ADYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713994-B2 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo,1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihyro-3 (2H)-isoquinolones and methods of use thereof | WYETH LLC (US) | 2010-05-11 | — | — | US | claimed |
| US-20080085890-A1 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof | WYETH (US) | 2008-04-10 | — | — | US | claimed |
| US-20080085890-A1 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof | WYETH (US) | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085890-A1 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof | SULT1E1, RECQL, HAX1 | CSF1R 4359/4885TNK2 873/4885DYRK3 1252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.